本文選題：益氣滋陰化瘀 + 非增殖期糖尿病視網(wǎng)膜病變��； 參考：《華北理工大學(xué)》2016年碩士論文

【摘要】：目的觀察益氣滋陰化瘀方對(duì)非增殖期糖尿病視網(wǎng)膜病變(Non-proliferative diabetic retinopathy,NPDR)(屬氣陰兩虛、瘀血阻絡(luò)證型)患者的臨床治療效果。方法選取2014年7月至2015年7月于唐山市中醫(yī)醫(yī)院內(nèi)分泌科住院治療的非增殖期糖尿病視網(wǎng)膜病變患者75例,按照隨機(jī)數(shù)字表法隨機(jī)分為治療組(n=37)和對(duì)照組(n=38)。兩組均給予常規(guī)降糖治療及其它疾病對(duì)癥治療,治療組在此基礎(chǔ)上服用益氣滋陰化瘀方,500ml/劑,1劑/日,250ml/次,2次/天。治療前及治療1個(gè)月后分別觀察患者中醫(yī)癥狀、視力及眼底病變、眼動(dòng)脈血流動(dòng)力學(xué)、FBG、PBG、HbA1c、肝功能、腎功能等的變化。結(jié)果1中醫(yī)證候積分及療效的比較:兩組患者在治療后較治療前中醫(yī)證候積分均有所下降(P0.05),但治療組中醫(yī)證候積分明顯低于對(duì)照組(7.24±5.75 vs11.77±6.79,P0.05)。且相對(duì)于對(duì)照組,加用益氣滋陰化瘀方的患者中醫(yī)癥狀治療效果明顯改善(82.3%vs 42.8%,P0.05)。2視力及眼底療效的比較:治療后兩組患者視力較治療前均有提高(P0.05),且治療組提高幅度明顯大于對(duì)照組(P0.05)。治療組眼底療效總有效率為85.3%,顯效27只(39.7%),有效31只(45.6%),無效10只(14.7%),未出現(xiàn)惡化的病例;對(duì)照組總有效率為48.6%,顯效14(20.0%),有效20只(28.6%),無效36只(51.4%),未出現(xiàn)惡化病例;治療組眼底病變改善情況明顯優(yōu)于對(duì)照組(P0.05)。3眼動(dòng)脈血流動(dòng)力學(xué)的比較:治療后兩組患者的眼動(dòng)脈血流動(dòng)力學(xué)指標(biāo)明顯比治療前有所改善(P0.05),且治療組血流速度提高及阻力指數(shù)降低的程度明顯大于對(duì)照組(P0.05)。4血糖和糖化血紅蛋白的比較:兩組在治療后比治療前血糖、糖化血紅蛋白均有所改善(P0.05),與對(duì)照組相比,治療組血糖、糖化血紅蛋白下降明顯,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。5肝功能和腎功能的比較:兩組患者治療前后肝功能和腎功能指標(biāo)比較無差異(P0.05)。結(jié)論益氣滋陰化瘀方可以降低血糖,改善中醫(yī)臨床癥狀,加快眼動(dòng)脈血流速度,減輕眼底病變程度,緩解或者逆轉(zhuǎn)糖尿病視網(wǎng)膜病變進(jìn)展,提高視力。
[Abstract]:Objective To observe the effect of Yiqi nourishing Yin Huayu Recipe on patients with non proliferative diabetic retinopathy (Non-proliferative diabetic retinopathy, NPDR) (belonging to deficiency of Qi and Yin, blood stasis syndrome). Methods the non proliferative diabetic retina hospitalized in the Department of Endocrinology, Tangshan City Hospital of traditional Chinese medicine from July 2014 to July 2015 75 patients were randomly divided into the treatment group (n=37) and the control group (n=38) according to the random number table. The two groups were given conventional hypoglycemic treatment and other diseases and symptomatic treatment. On this basis, the treatment group took Yiqi nourishing Yin Huayu Recipe, 500ml/ agent, 1 doses / day, 250ml/ times, 2 times. The patients' symptoms were observed before and after 1 months of treatment, respectively. Changes in visual acuity and fundus lesions, ophthalmic artery hemodynamics, FBG, PBG, HbA1c, liver function and renal function. Results 1 TCM syndrome scores and curative effects were compared: the scores of TCM syndrome in the two groups were decreased after treatment (P0.05), but the score of TCM syndrome in the treatment group was significantly lower than that of the control group (7.24 + 5.75 vs11.77 + 6.79, P0.05). Compared with the control group, the curative effect of TCM symptom treatment was obviously improved (82.3%vs 42.8%, P0.05).2 visual acuity and fundus curative effect. The visual acuity of the two groups was improved after treatment (P0.05), and the improvement of the treatment group was significantly greater than that of the control group (P0.05). The total effective rate of the treatment group was 85.. 3%, 27 (39.7%), 31 effective (45.6%), 10 ineffective (14.7%) and no worsening cases; the control group had a total effective rate of 48.6%, an effective 14 (20%), an effective 20 (28.6%), no invalid 36 (39.7%), no worsening cases; the improvement of the fundus disease in the treatment group was significantly better than the comparison group (P0.05).3 ophthalmic hemodynamic comparison: treatment after treatment The hemodynamic indexes of the two groups were significantly better than those before the treatment (P0.05), and the improvement of blood flow velocity and resistance index in the treatment group was significantly greater than that of the control group (P0.05).4 blood sugar and glycosylated hemoglobin: the two groups improved after treatment than before the treatment of blood sugar and glycosylated hemoglobin (P0.05), and the control group. Compared with the treatment group, the blood sugar, glycated hemoglobin decreased significantly, the difference was statistically significant (P0.05).5 liver function and renal function comparison: the two groups of patients before and after treatment of liver function and renal function indexes have no difference (P0.05). Conclusion Yiqi nourishing yin and Huayu Recipe can reduce blood sugar, improve the clinical symptoms of traditional Chinese medicine, speed up the velocity of ocular artery blood flow, reduce the blood flow rate and decrease the blood flow rate of the ophthalmic artery. The degree of mild fundus lesions relieves or reverses the progression of diabetic retinopathy and improves vision.

【學(xué)位授予單位】：華北理工大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R276.7

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