【摘要】：目的:探討辛伐他汀保護高脂飲食致腎臟損傷的新機制。方法:雌性SD大鼠隨機分為標準飲食組、高脂飲食組及辛伐他汀治療組,高脂飲食組和辛伐他汀治療組先予高脂飲食20周,后者在高脂飲食的同時予辛伐他汀~([10 mg/(kg·d)])灌胃治療8周。分析大鼠血脂和腎臟的病理學(xué)變化、腎臟中脂聯(lián)素、脂聯(lián)素受體R1,R2,AMP依賴的蛋白激酶(AMPK),過氧化物酶體增殖物激活受體α(PPARα)、葡萄糖調(diào)節(jié)蛋白78(GRP78)和轉(zhuǎn)錄因子GADD153(CHOP)的表達。結(jié)果:高脂飲食組大鼠體質(zhì)和血脂水平明顯增高,脂聯(lián)素及其受體表達明顯下調(diào),AMPKα磷酸化降低,PPARα表達降低,GRP78和CHOP基因表達水平均明顯上調(diào)。辛伐他汀治療組上述指標均出現(xiàn)明顯改善。結(jié)論:辛伐他汀可能通過升高腎臟脂聯(lián)素及其受體的表達,減少內(nèi)質(zhì)網(wǎng)應(yīng)激來改善高脂誘導(dǎo)的大鼠腎臟損傷。
[Abstract]:Objective: to investigate the new mechanism of simvastatin in protecting kidney injury induced by high fat diet. Methods: female SD rats were randomly divided into standard diet group, high-fat diet group and simvastatin treatment group, high-fat diet group and simvastatin treatment group were given high-fat diet for 20 weeks, the latter was given simvastatin ~ (10 mg/ (kg 路d) intragastrically for 8 weeks. The pathological changes of blood lipid and kidney, the expression of adiponectin, adiponectin receptor R1, R2, (AMPK), peroxisome proliferator activated receptor 偽 (PPAR 偽), glucose regulated protein 78 (GRP78) and transcription factor GADD153 (CHOP) in kidney were analyzed. Results: in the high fat diet group, the levels of physique and blood lipid were significantly increased, the expression of adiponectin and its receptor was significantly down-regulated, the phosphorylation of AMPK 偽 was decreased, the expression of PAPAR 偽 was decreased, and the expression of GRP78 and CHOP genes was significantly up-regulated. The above indexes were significantly improved in simvastatin treatment group. Conclusion: simvastatin may improve renal injury induced by high fat by increasing the expression of adiponectin and its receptor in kidney and reducing endoplasmic reticulum stress.
【作者單位】： 安徽醫(yī)科大學(xué)生物化學(xué)教研室;安徽醫(yī)科大學(xué)第一附屬醫(yī)院內(nèi)分泌科;
【基金】：國家中醫(yī)臨床研究基地業(yè)務(wù)建設(shè)專項課題(編號:JDZX2015129)
【分類號】：R965

【參考文獻】

相關(guān)期刊論文 前2條

1 徐芬;郝華;戴華;李里香;曾磊;;脂氧素對脂多糖誘導(dǎo)的人近曲腎小管上皮細胞氧化應(yīng)激的影響及機制[J];實用醫(yī)學(xué)雜志;2017年01期

2 殷曉明;涂玲;楊慧清;;Effect of Simvastatin on IL-6 and Adiponectin Secretion and mRNA Ex- pression in 3T3-L1 Adipocytes[J];Journal of Huazhong University of Science and Technology(Medical Sciences);2007年03期

【共引文獻】

相關(guān)期刊論文 前2條

1 朱致祥;李朝飛;陳勇;章秋;魯云霞;;辛伐他汀通過增加脂聯(lián)素及其受體的表達改善高脂飲食引起的腎臟損傷[J];實用醫(yī)學(xué)雜志;2017年11期

2 陳新忠;焦周陽;汪雷;孫宗全;魏玉濤;王現(xiàn)國;夏東升;;Roles of Human Epicardial Adipose Tissue in Coronary Artery Atherosclerosis[J];Journal of Huazhong University of Science and Technology(Medical Sciences);2010年05期

【二級參考文獻】

相關(guān)期刊論文 前1條

1 戴華;李里香;郝華;徐芬;;BML-111下調(diào)骨橋蛋白對脂多糖誘導(dǎo)的Hela細胞增殖的影響及其機制[J];實用醫(yī)學(xué)雜志;2015年03期

【相似文獻】

相關(guān)期刊論文 前3條

1 鄭建雷;陳秋靜;陸林;張奇;張瑞巖;沈衛(wèi)峰;;阿托伐他汀對高脂飲食糖尿病大鼠主動脈幾丁質(zhì)酶-3樣蛋白-1表達的影響[J];中國臨床藥理學(xué)與治療學(xué);2014年02期

2 王斌;管思明;李西棟;;纈沙坦對高脂飲食喂養(yǎng)家兔核因子-κB及炎癥因子表達的影響[J];中國醫(yī)院藥學(xué)雜志;2008年09期

3 余勤;李建生;李道明;張志宇;段艷峰;趙志華;秦炎軍;張會娟;;二甲雙胍對大鼠高脂飲食性脂肪肝的預(yù)防和治療作用[J];醫(yī)藥論壇雜志;2010年17期

，

本文編號：2516753