【摘要】：對1株喜樹內生真菌Diaporthe sp.XZ-07的次生代謝產(chǎn)物進行研究。采用RP-18,Sephadex LH-20,硅膠等材料進行色譜柱分離純化得到2個新化合物,鑒定為5-((E)-1,4,5-trihydroxyhex-2-enyl)furan-2(5H)-one(1)和(5Z)-5-(2,3,4,5-tetrahydroxyhexylidene)furan-2(5H)-one(2)。用MTT法測試化合物活性,結果顯示化合物1對Hela有較強抑制活性,化合物2對MCF-7,SH-SY5Y,3LL均有較強抑制活性。
[Abstract]:The secondary metabolites of Diaporthe sp.XZ-07 from an endophytic fungus of Camptotheca acuminata were studied. Two new compounds were isolated and purified on RP-18,Sephadex LH-20, silica gel column. They were identified as 5-(E)-1,4,5-trihydroxyhexa-furan-2 (5H)-one (1) and (5Z)-5-(2,3,3,5) furan-2 (5H)-one (1) and (5Z)-5-(2,3,3,5Z). 4,5-tetrahydroxyhexylidene furan-2 (5H)-one (2). The activity of compound 1 was tested by MTT method. The results showed that compound 1 had strong inhibitory activity on Hela and compound 2 had strong inhibitory activity on MCF-7,SH-SY5Y,3LL.
【作者單位】： 昆明學院化學科學與技術系;中國科學院昆明植物研究所;
【基金】：國家自然科學基金項目(31260073)
【分類號】：R96;R915

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