本文選題：非達(dá)霉素 + 高純度��； 參考：《中國抗生素雜志》2017年02期

【摘要】：目的開發(fā)一種高純度非達(dá)霉素的制備工藝。方法采用DAC50高壓制備色譜系統(tǒng),優(yōu)化了制備工藝。結(jié)果選用Kromasil C_8作為色譜填料,洗脫劑為50%乙腈加0.1%甲酸,上樣量為1.4~1.6g粗品,純化后產(chǎn)品純度≥99.5%,單雜≤0.10%,純化收率在85%左右。結(jié)論該工藝簡單高效,適用于工業(yè)化規(guī)模生產(chǎn)。
[Abstract]:Objective to develop a preparation process of high purity nidamicin. Methods DAC 50 high pressure preparation chromatography system was used to optimize the preparation process. Results Kromasil CStu8 was used as the chromatographic filler, the eluant was 50% acetonitrile plus 0.1% formic acid, the sample amount was 1.4 ~ 1.6 g crude product, the purity of the purified product was 鈮，

本文編號：2057477