發(fā)布時(shí)間：2018-06-22 06:43

  本文選題：環(huán)孢素A + 兒童��； 參考：《中國(guó)藥房》2015年09期

【摘要】：目的:考察環(huán)孢素A口服溶液不同給藥劑量對(duì)一次性注射器內(nèi)殘留量的影響。方法:將40支一次性無(wú)菌注射器均分為0.9%氯化鈉注射液組和環(huán)孢素A口服溶液組,兩組又均分為4個(gè)亞組。分別測(cè)定兩組注射器內(nèi)溶液的殘留量,并計(jì)算殘留百分比。結(jié)果:環(huán)孢素A口服溶液組各亞組一次性無(wú)菌注射器內(nèi)環(huán)孢素A的殘留百分比均顯著高于0.9%氯化鈉注射液組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。環(huán)孢素A口服溶液各亞組間除0.5 ml組與0.8 ml組間比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)外,其他各組間比較差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:兒童采用一次性無(wú)菌注射器口服給予環(huán)孢素A時(shí)抽取的劑量越小,注射器內(nèi)藥物的殘留百分比越大;當(dāng)注射器抽取環(huán)孢素A溶液劑量在0.1 ml時(shí),注射器內(nèi)藥物的殘留量百分比最高。
[Abstract]:Objective: to investigate the effect of different dosages of cyclosporine A oral solution on the residues in disposable syringes. Methods: 40 disposable sterile syringes were divided into 0.9% sodium chloride injection group and an oral cyclosporine A solution group. The two groups were divided into 4 subgroups. The residual amount of solution in two groups of syringes was determined and the percentage of residual solution was calculated. Results: the percentage of residual cyclosporine A in single sterile syringe in the oral solution group was significantly higher than that in 0.9% sodium chloride injection group (P0.05). There was no significant difference between each subgroup of CSA oral solution except 0.5 ml group and 0.8 ml group (P0.05), but there were significant differences among other groups (P0.05). Conclusion: the smaller the dose of cyclosporine A is, the greater the residual percentage of drugs in the syringe is, when the dose of cyclosporine A solution is 0.1 ml, and the dose of cyclosporine A solution is 0.1 ml when the dose of cyclosporine A solution is 0.1 ml. The highest percentage of drug residues were found in syringes.
【作者單位】： 北京大學(xué)第一醫(yī)院藥劑科;
【分類號(hào)】：R96

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