【摘要】：目的評(píng)價(jià)脫細(xì)胞膀胱基質(zhì)作為盆底修復(fù)替代材料的生物相容性。方法通過細(xì)胞毒性試驗(yàn)、溶血試驗(yàn)、陰道埋植試驗(yàn)等體內(nèi)外生物學(xué)實(shí)驗(yàn)相結(jié)合的方法評(píng)價(jià)該材料的生物相容性。結(jié)果在細(xì)胞毒性試驗(yàn)中,材料毒性級(jí)別0~1級(jí)。材料浸提液的溶血率為1.5%。大體和組織學(xué)觀察示材料未引起宿主免疫排斥反應(yīng),植入后引起輕度的異物反應(yīng),移植12周后基本降解。結(jié)論該材料具有良好的生物相容性,但需調(diào)整其降解率,以適應(yīng)盆底修復(fù)手術(shù)要求。
[Abstract]:Objective to evaluate the biocompatibility of acellular bladder matrix as an alternative material for pelvic floor repair. Methods the biocompatibility of the material was evaluated by cytotoxicity test, hemolysis test, vaginal implantation test and other biological experiments in vitro and in vivo. Results in the cytotoxicity test, the toxicity grade of the material was 0 鈮，

本文編號(hào)：2507203