本文選題：浮動(dòng)基準(zhǔn)法 + 葡萄糖濃度檢測　； 參考：《光譜學(xué)與光譜分析》2012年03期

【摘要】：近紅外無創(chuàng)血糖濃度測量面臨著信號(hào)微弱、儀器信噪比低、血液中其他成分干擾以及人體生理環(huán)境不斷變化等因素影響,致使血糖信號(hào)難以辨識(shí)這一難題。浮動(dòng)基準(zhǔn)法針對(duì)葡萄糖濃度變化對(duì)吸收和散射效應(yīng)的影響,選擇吸收效應(yīng)和散射效應(yīng)相互抵消的位置獲得基準(zhǔn)光譜,在吸收和散射效應(yīng)引起最大綜合影響的位置獲得測量光譜,并采用基準(zhǔn)光譜對(duì)測量光譜進(jìn)行修正,從而消減樣品背景狀態(tài)變化以及儀器噪聲、漂移等干擾。通過應(yīng)用實(shí)驗(yàn)評(píng)估浮動(dòng)基準(zhǔn)法對(duì)提高模型預(yù)測精度和穩(wěn)定性的有效性。通過對(duì)處理前后的預(yù)測結(jié)果進(jìn)行比較分析得出:應(yīng)用浮動(dòng)基準(zhǔn)法數(shù)據(jù)處理之后,交互驗(yàn)證均方根誤差(RMSEP)最大改進(jìn)比率34.7%,實(shí)驗(yàn)結(jié)果表明浮動(dòng)基準(zhǔn)法能夠有效消減樣品自身狀態(tài)變化以及儀器噪聲、漂移等干擾因素的影響,較大幅度地提高了模型的預(yù)測性能和穩(wěn)定性,以期突破無創(chuàng)血糖濃度測量的障礙。
[Abstract]:Near-infrared noninvasive blood glucose concentration measurement is faced with weak signal, low signal-to-noise ratio of instrument, interference of other components in blood and changing physiological environment of human body, which makes it difficult to identify the blood glucose signal. In view of the effect of glucose concentration variation on absorption and scattering effect, the floating reference method selects the position where the absorption effect and scattering effect cancel each other to obtain the reference spectrum, and obtains the measurement spectrum at the position where the absorption and scattering effects cause the most comprehensive effect. The reference spectrum is used to modify the measurement spectrum to reduce the background state change of the sample and the interference of instrument noise and drift. The effectiveness of the floating benchmark method in improving the prediction accuracy and stability of the model is evaluated by experiments. By comparing and analyzing the prediction results before and after processing, it is concluded that the floating datum method is used to process the data. The experimental results show that the floating reference method can effectively reduce the influence of disturbance factors such as instrument noise and drift. The predictive performance and stability of the model are greatly improved in order to break the barrier of noninvasive blood glucose concentration measurement.
【作者單位】： 天津市生物醫(yī)學(xué)檢測技術(shù)及儀器重點(diǎn)實(shí)驗(yàn)室;天津市先石光學(xué)技術(shù)有限公司博士后創(chuàng)新實(shí)踐基地;天津大學(xué)精密測試技術(shù)及儀器國家重點(diǎn)實(shí)驗(yàn)室;
【基金】：國家自然科學(xué)基金重點(diǎn)項(xiàng)目(60938002) 天津市生物醫(yī)學(xué)檢測技術(shù)及儀器重點(diǎn)實(shí)驗(yàn)室開放基金項(xiàng)目資助
【分類號(hào)】：G649.1
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本文編號(hào)：1947405