【摘要】：目的觀察育陰清熱補(bǔ)沖湯治療腎陰虛型經(jīng)間期出血的臨床療效,并將其與中成藥宮環(huán)養(yǎng)血顆粒合知柏地黃丸對照,觀察兩組藥物治療后的患者出血的情況、各中醫(yī)癥狀以及基礎(chǔ)體溫的變化情況。初步探討其作用機(jī)理,為育陰清熱補(bǔ)沖湯運用到臨床治療提供科學(xué)的依據(jù)。方法選擇符合本課題研究標(biāo)準(zhǔn)且門診確診為經(jīng)間期出血患者60例,隨機(jī)分為兩組,治療組患者30例,口服自擬方育陰清熱補(bǔ)沖湯,對照組患者30例,口服宮環(huán)養(yǎng)血顆粒合知柏地黃丸。均于月經(jīng)周期的第7～10天開始,連續(xù)服用10天,共觀察三個月經(jīng)周期。治療前和治療期間每個月經(jīng)周期后均需記錄兩組患者服用藥物后的出血情況、各中醫(yī)癥狀的變化情況,治療期間需每日測定并記錄基礎(chǔ)體溫,最后對患者的療效、各個單項癥狀積分、臨床癥狀總積分及基礎(chǔ)體溫雙相曲線的典型人數(shù)進(jìn)行組內(nèi)及組間的差異性、相關(guān)性分析。以上所有數(shù)據(jù)應(yīng)用SPSS22.0統(tǒng)計軟件進(jìn)行分析,以檢驗結(jié)果為p0.05為差異有統(tǒng)計學(xué)意義。結(jié)果1.治療后,治療組總有效率86.7%,對照組總有效率80.0%,組間相比,差異具有統(tǒng)計學(xué)意義(p0.05),治療組優(yōu)于對照組。2.治療后,兩組出血情況及各中醫(yī)癥狀均有所改善。治療前后具有顯著差異(p0.01)；出血情況組間相比,差異具有統(tǒng)計學(xué)意義(p0.05),各中醫(yī)癥狀積分組間相比,無統(tǒng)計學(xué)差異(p0.05)。治療組止血效果優(yōu)于對照組,改善中醫(yī)癥狀方面療效相當(dāng)。3.治療期間,治療組一、二療程和二、三療程的BBT雙相曲線典型人數(shù)比較均無統(tǒng)計學(xué)差異(p0.05),一、三療程比較差異具有統(tǒng)計學(xué)意義(p0.05)；對照組患者治療一、二、三療程后的雙相曲線典型人數(shù)兩兩比較差異無統(tǒng)計學(xué)意義(p0.05)。治療組藥物至少使用三個療程才可改善BBT雙相曲線不典型狀態(tài)。4.治療組療程越長,療效越好(p0.01)。結(jié)論1.育陰清熱補(bǔ)沖湯能夠有效的治療腎陰虛型經(jīng)間期出血,可明顯地改善伴隨癥狀和BBT雙相曲線不典型狀態(tài),且服藥時間越長,療效越好。2.臨床觀察過程中,服用育陰清熱補(bǔ)沖湯無不良反應(yīng)出現(xiàn)。
[Abstract]:Objective to observe the clinical effect of Yuyin Qingre Buchong decoction (YQRBT) in treating interphase hemorrhage of kidney yin deficiency type, and compare it with traditional Chinese patent medicine Gong Huan Yang Xue granule and Zhibai Dihuang Pill, and observe the bleeding of patients in two groups after drug treatment. Changes of TCM symptoms and basic body temperature. To provide scientific basis for the application of Yuyin Qingre Buchong decoction to clinical treatment. Methods A total of 60 patients with interphase hemorrhage were randomly divided into two groups: the treatment group (n = 30) and the control group (n = 30). Oral Gonghuan Yangxue granule and Zhibai Dihuang pills. They were taken continuously for 10 days from the 7th day of menstrual cycle. Three menstrual cycles were observed. Before treatment and after each menstrual cycle during treatment, the bleeding after taking drugs, the changes of symptoms of each TCM should be recorded, the basic body temperature should be measured and recorded daily during the treatment period, and finally the curative effect on the patients should be recorded. The difference and correlation between groups were analyzed by the typical number of individual symptom score, clinical symptom score and basic body temperature biphasic curve. All the above data were analyzed by SPSS22.0 software. Result 1. After treatment, the total effective rate of the treatment group was 86.7 and the total effective rate of the control group was 80.0. The difference between the two groups was statistically significant (p0.05), and the treatment group was better than the control group. After treatment, the two groups of bleeding and the symptoms of traditional Chinese medicine have been improved. There were significant differences before and after treatment (p0.01), bleeding between groups, the difference was statistically significant (p0.05), there was no statistical difference between the TCM symptom score group (p0.05). The hemostatic effect of the treatment group was better than that of the control group. During the treatment period, there was no significant difference in the typical number of BBT biphasic curves between the first, second and third courses of treatment in the treatment group (p0.05), but there was significant difference between the first and third courses of treatment (p0.05). In the control group, there was no significant difference in the number of patients with bipolar curve after one, two and three courses of treatment (p0.05). Treatment group drug use at least three courses of treatment to improve the BBT bipolar curve atypical state. 4. The longer the course of treatment, the better the curative effect (p 0.01). Conclusion 1. Yuyin Qingre Buchong decoction can effectively treat the kidney yin deficiency type of intermenstrual hemorrhage, can obviously improve the accompanying symptoms and the atypical state of BBT biphasic curve, and the longer the treatment time, the better the curative effect. 2. In the course of clinical observation, there was no adverse reaction after taking Yuyin Qingre Buchong decoction.
【學(xué)位授予單位】：黑龍江中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R271.11

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