醒智散治療阿爾茨海默病的臨床研究
[Abstract]:Objective: to observe the clinical efficacy and safety of Xingzhisan combined with clinical experience in treating Alzheimer's disease, and to explore the mechanism of its action so as to provide clinical evidence for giving full play to the advantages of TCM differentiation of symptoms and signs. Methods: according to the criteria of traditional Chinese medicine diagnosis, western medicine diagnosis and case selection, from January 2015 to March 2016, the Department of Integrated traditional Chinese Medicine and Western Medicine was included in the Yantai Yuding Hospital affiliated to Qingdao University for Alzheimer's disease. There were 62 inpatients in neurology department. According to the order of hospitalization, the patients were randomly divided into treatment group (n = 32) and control group (n = 30). The patients in the treatment group were given 5mg orally every day, and on the basis of this, the patients in the treatment group were given 1 dose of 300ml once a day, twice in the morning and evening, while those in the control group were given only 5mg orally every day. The course of treatment was 12 weeks. The cognitive function and the severity of dementia were evaluated by (MMSE), Hasegawa Intelligence improvement scale (HDS-R) and the ability of Daily living scale (ADL) was used to evaluate the ability of daily living (ADL). TCM syndromes integral table can evaluate the improvement of TCM syndromes. Before and after treatment, the MMSE,HDS,ADL, TCM syndromes were measured and the safety of medication was evaluated. The statistical software of SPSS19.0 was used to analyze the data. The measurement data are tested by independent sample t-test or paired sample t-test; counting data are tested by c2 test or Fisher exact probability test according to the range of theoretical frequency; and rank data are tested by Wilcoxon rank sum test. The statistical data were described by mean 鹵standard deviation (x -) 鹵s. All the indexes were tested on both sides, P0.05 for the difference was statistically significant, P0.01 for the difference was statistically significant. Results: compared with the two groups, the total effective rate of the treatment group was 81%, the total effective rate of the control group was 73%, the total effective rate of the treatment group was better than that of the control group (P0.05). Comparison of TCM syndromes between the two groups: the total effective rate of the treatment group was 84g, the total effective rate of the control group was 67kum, the total effective rate of the treatment group was better than that of the control group (P0.05); The main symptoms of the two groups of patients compared with the score: the two groups of symptoms after treatment were lower than before treatment (P0.05), and the treatment group was significantly lower than the control group (P0.05); Comparison of MMSE scores between the two groups: except the memory item control group had no statistical significance after treatment (P0.05), the other two groups had higher scores after treatment than before (P0.01). The treatment group was significantly higher than the control group (P0.01). Comparison of HDS-R scale scores between the two groups: the scores of the two groups were increased after treatment (P0.01), and the improvement of the treatment group was significantly higher than that of the control group (P0.01). Comparison of ADL scores between the two groups: after treatment, the scores in both groups were lower than those before treatment (P0.01), and the scores in the treatment group were significantly lower than those in the control group (P0.01). Before and after treatment, no abnormality was found in blood, urine, stool routine, liver, renal function and electrocardiogram. Conclusion: the total effective rate of Xingzhi San combined with Anlisin in the treatment of Alzheimer's disease is 81, which can obviously improve the cognitive function, self-care ability of daily life and the severity of dementia in patients with Alzheimer's disease. It can improve the curative effect of TCM syndromes and clinical curative effect, at the same time, it has higher safety, can delay the development of disease and improve the living condition of patients with Alzheimer's disease.
【學(xué)位授予單位】:青島大學(xué)
【學(xué)位級別】:碩士
【學(xué)位授予年份】:2017
【分類號】:R277.7
【參考文獻(xiàn)】
相關(guān)期刊論文 前10條
1 平衛(wèi)燕;陳燕清;侯亞文;楊晶晶;;淺議肝與老年性癡呆發(fā)病的關(guān)系[J];中國民族民間醫(yī)藥;2015年24期
2 周蕾;;老年癡呆病中醫(yī)與西醫(yī)研究進(jìn)展[J];中國現(xiàn)代藥物應(yīng)用;2015年20期
3 曹惠敏;余剛;;Nrf2在阿爾茨海默病中的研究現(xiàn)狀[J];生物化學(xué)與生物物理進(jìn)展;2015年06期
4 鄭英宇;陳民;;健脾祛痰化瘀治療老年癡呆[J];實用中醫(yī)內(nèi)科雜志;2015年07期
5 侯燕;陳民;;老年癡呆中醫(yī)學(xué)術(shù)源流探析[J];遼寧中醫(yī)藥大學(xué)學(xué)報;2015年06期
6 黎鼎盛;;中西醫(yī)結(jié)合治療老年癡呆60例臨床觀察[J];湖南中醫(yī)雜志;2015年04期
7 曹現(xiàn)芳;侯亞男;;老年癡呆病的發(fā)病機制與藥物作用[J];中國現(xiàn)代藥物應(yīng)用;2015年07期
8 董賢慧;柴錫慶;;阿爾茨海默病發(fā)病機制研究進(jìn)展[J];中國老年學(xué)雜志;2014年20期
9 陳原鄰;劉喜明;;阿爾茨海默病的中西醫(yī)治療進(jìn)展[J];世界中醫(yī)藥;2014年01期
10 金范瑩;張寶榮;;老年癡呆的遺傳機制研究進(jìn)展[J];生命科學(xué);2014年01期
相關(guān)碩士學(xué)位論文 前1條
1 劉姝男;人參多糖及其組分抗老年癡呆的有效性研究[D];吉林大學(xué);2014年
,本文編號:2352359
本文鏈接:http://www.sikaile.net/zhongyixuelunwen/2352359.html