本文選題：補(bǔ)腎降壓方 + 補(bǔ)腎益心片　； 參考：《廣州中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的：高血壓的治療目標(biāo)是包括降壓在內(nèi)的靶器官保護(hù)、總體心血管風(fēng)險(xiǎn)降低以及生活質(zhì)量的提高。本研究旨在通過(guò)探討補(bǔ)腎法(補(bǔ)腎降壓方與補(bǔ)腎益心片)治療輕中度高血壓患者降壓療效、中醫(yī)證候及病人生活質(zhì)量改善情況,總結(jié)臨床經(jīng)驗(yàn),為中醫(yī)臨床辨治高血壓進(jìn)一步提供有益的依據(jù)。方法：本研究擬采用前瞻性隨機(jī)對(duì)照的臨床研究方法,根據(jù)《中藥新藥臨床研究指導(dǎo)原則》,納入臨床上診斷為腎虛型高血壓患者100例。將患者隨機(jī)分成兩組,其中治療組50例和對(duì)照組50例。治療組予基礎(chǔ)西藥苯磺酸氨氯地平片1片QD降壓加用補(bǔ)腎降壓方與補(bǔ)腎益心片治療；對(duì)照組予基礎(chǔ)西藥苯磺酸氨氯地平片1片QD降壓,療程觀察為3個(gè)月。然后觀察并統(tǒng)計(jì)評(píng)估治療前后患者血壓、中醫(yī)證侯評(píng)分、病人生理狀況、工作狀態(tài)、睡眠、生活質(zhì)量等臨床療效。結(jié)果：臨床研究表明,兩組均具有良好的降壓效果,降壓總有效率(治療組VS對(duì)照組：95% VS 90%)；24h動(dòng)態(tài)血壓療效觀察：治療前后兩組谷峰比及平滑指數(shù)組內(nèi)比較均具有統(tǒng)計(jì)學(xué)顯著性差異,兩組治療前后谷峰比與平滑指數(shù)組間差值比較均具有統(tǒng)計(jì)學(xué)顯著差異(p0.01),治療組優(yōu)于對(duì)照組；生活質(zhì)量改善方面,治療前后兩組多項(xiàng)指標(biāo)均有改善,但治療組明顯優(yōu)于對(duì)照組指標(biāo)。進(jìn)一步表明對(duì)于腎虛型高血壓患者,在常規(guī)運(yùn)用苯磺酸氨氯地平片進(jìn)行降壓的同時(shí),使用中醫(yī)藥補(bǔ)腎降壓方與補(bǔ)腎益心片治療進(jìn)一步提高了單純使用西藥的療效。結(jié)論：在常規(guī)苯磺酸氨氯地平片降壓治療的基礎(chǔ)上,并給予補(bǔ)腎降壓方與補(bǔ)腎益心片中醫(yī)辨證治療,可進(jìn)一步平穩(wěn)控制血壓,改善患者生活質(zhì)量,如軀體化狀況、生理癥狀、工作狀態(tài)、睡眠改善等。同時(shí),也為中醫(yī)運(yùn)用湯劑與片劑聯(lián)合辨證論治高血壓病提供了實(shí)用的方法和依據(jù)。
[Abstract]:Objective: the aim of treatment for hypertension is to protect target organs including hypotension, reduce overall cardiovascular risk and improve quality of life. The purpose of this study was to summarize the clinical experience of Bushen Jiangya decoction and Bushen Yixin tablet in the treatment of patients with mild and moderate hypertension by exploring the antihypertensive effect, TCM syndromes and the improvement of patients' quality of life. To provide a useful basis for the clinical treatment of hypertension. Methods: a prospective randomized controlled clinical study was carried out in 100 cases of hypertension with kidney deficiency according to the guiding principles of New Chinese Medicine Clinical Research. Patients were randomly divided into two groups: treatment group (n = 50) and control group (n = 50). The treatment group was treated with basic western medicine amlodipine benzenesulfonic acid (QD) 1 tablet QD combined with Bushen Jiangya decoction and Bushen Yixin tablet while the control group was treated with basic western medicine amlodipine benzenesulfonic acid 1 tablet QD and the course of treatment was observed for 3 months. Then observe and evaluate the clinical effect of blood pressure, TCM syndrome score, patient's physiological status, working state, sleep, quality of life before and after treatment. Results: the clinical study showed that both groups had good antihypertensive effect and the total effective rate was 90% (vs control group: 95% vs 90%). Observation of 24-hour ambulatory blood pressure: there were significant differences between the two groups before and after treatment. The difference between the two groups before and after treatment was statistically significant (p0.01), the treatment group was better than the control group, the improvement of quality of life, the two groups before and after treatment of a number of indicators improved, But the treatment group was better than the control group. It is further indicated that the traditional use of amlodipine benzenesulfonic acid tablets for lowering blood pressure, the use of traditional Chinese medicine Bushen Jiangya prescription and Bushen Yixin tablet to further improve the efficacy of the use of western medicine. Conclusion: on the basis of antihypertensive therapy of amlodipine benzenesulfonic acid tablets and traditional Chinese medicine differentiation treatment of Bushen Jiangya decoction and Bushen Yixin tablet, the blood pressure can be controlled steadily and the quality of life of patients can be improved, such as somatization and physiological symptoms. Work status, sleep improvement, etc. At the same time, it also provides the practical method and basis for the treatment of hypertension with decoction and tablet combined with syndrome differentiation.
【學(xué)位授予單位】：廣州中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 付寧;曲怡;張立德;;熱敏灸干預(yù)高血壓前期的思路探討[J];遼寧中醫(yī)藥大學(xué)學(xué)報(bào);2016年02期

2 王天平;舒一容;王凱忠;;中醫(yī)辨證分型聯(lián)合西藥治療老年高血壓臨床觀察[J];光明中醫(yī);2015年03期

3 吳啟鳳;張彩靈;;降低高血壓的中藥材研究[J];中國(guó)社區(qū)醫(yī)師;2014年28期

4 朱夢(mèng)軍;;松齡血脈康膠囊與硝苯地平控釋片治療原發(fā)性高血壓療效對(duì)比研究[J];亞太傳統(tǒng)醫(yī)藥;2013年12期

5 卿立金;吳偉;;吳偉教授從腎論治高血壓病經(jīng)驗(yàn)[J];中國(guó)中醫(yī)急癥;2013年12期

6 鄭秀棉;楊莉;王崢濤;;車前子的化學(xué)成分與藥理活性研究進(jìn)展[J];中藥材;2013年07期

7 李婷;王居新;崔雪峰;;耳穴壓豆療法治療高血壓100例療效觀察[J];云南中醫(yī)中藥雜志;2012年11期

8 林寬;;降壓膠囊治療肝火亢盛型原發(fā)性高血壓病療效觀察[J];山西中醫(yī);2012年10期

9 馬茂森;;糖皮質(zhì)激素的副作用及并發(fā)癥治療[J];中國(guó)城鄉(xiāng)企業(yè)衛(wèi)生;2011年03期

10 李培林;;五倍子瀉心湯加減治療高血壓[J];中國(guó)中醫(yī)藥現(xiàn)代遠(yuǎn)程教育;2011年01期

相關(guān)碩士學(xué)位論文 前3條

1 劉鵬飛;八段錦運(yùn)動(dòng)治療高血壓的臨床觀察[D];廣州中醫(yī)藥大學(xué);2014年

2 徐琳;宮麗鴻教授治療眩暈的經(jīng)驗(yàn)初探[D];遼寧中醫(yī)藥大學(xué);2009年

3 郜玲;補(bǔ)腎降壓方對(duì)輕中度高血壓患者生活質(zhì)量的影響[D];廣州中醫(yī)藥大學(xué);2007年

，

本文編號(hào)：2113274