本文選題：輸卵管性不孕癥 + 證型��； 參考：《河南中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:通過(guò)檢索近15年國(guó)內(nèi)外發(fā)表有關(guān)輸卵管性不孕癥(tubal factor infertility,TFI)證型及相關(guān)危險(xiǎn)因素的文獻(xiàn),統(tǒng)計(jì)出本病臨床常見(jiàn)中醫(yī)證型,采用Meta分析來(lái)綜合評(píng)價(jià)TFI臨床常見(jiàn)致病危險(xiǎn)因素及其關(guān)聯(lián)強(qiáng)度,為該病的早期預(yù)測(cè)提供循證依據(jù)從而提高我們對(duì)本病的認(rèn)識(shí)及診斷治療水平。方法:通過(guò)Pubmed、Cochrane、SCI數(shù)據(jù)庫(kù)、CNKI、萬(wàn)方、維普等數(shù)據(jù)庫(kù)進(jìn)行網(wǎng)上檢索,同時(shí)手工檢索河南中醫(yī)學(xué)院圖書(shū)館2000年以后關(guān)于TFI的書(shū)籍、雜志等,并對(duì)納入文獻(xiàn)的參考文獻(xiàn)進(jìn)行篩查檢索。根據(jù)已制定的納入標(biāo)準(zhǔn)及排除標(biāo)準(zhǔn)對(duì)所檢索到的文獻(xiàn)進(jìn)行分類(lèi)及篩選,以中醫(yī)證型和相關(guān)危險(xiǎn)因素為信息點(diǎn)對(duì)符合要求的文獻(xiàn)進(jìn)行信息提取及統(tǒng)計(jì)分析。結(jié)果:最終共納入5篇有關(guān)TFI中醫(yī)證型方面的文獻(xiàn),進(jìn)行統(tǒng)計(jì)分析后結(jié)果如下:TFI中醫(yī)證型分布以氣滯血瘀型、腎虛血瘀型、濕熱瘀組型為主,其中氣滯血瘀型占53.5%、腎虛血瘀型占18.5%、濕熱瘀組型占17.3%。最終共納入7篇有關(guān)TFI相關(guān)危險(xiǎn)因素的文獻(xiàn)。進(jìn)行Meta分析結(jié)果如下:盆腔炎病史:合并效應(yīng)量OR值為5.44,95%CI(2.75,10.78),P0.05,其差異具有統(tǒng)計(jì)學(xué)意義。人工流產(chǎn)史:合并效應(yīng)量OR值為1.30,95%CI(0.98,1.74),P0.05,其差異無(wú)統(tǒng)計(jì)學(xué)意義。闌尾炎史:合并效應(yīng)量OR值為3.23,95%CI(1.64,6.35),P0.05,其差異具有統(tǒng)計(jì)學(xué)意義。初次性生活年齡20歲:合并效應(yīng)量OR值為3.46,95%CI(2.11,5.68),P0.05,其差異具有統(tǒng)計(jì)學(xué)意義。異位妊娠史:合并效應(yīng)量OR值為7.80,95%CI(3.82,15.93),P0.05,其差異具有統(tǒng)計(jì)學(xué)意義。NG/CT/UU感染史:合并效應(yīng)量OR值為6.68,95%CI(3.69,12.11),P0.05,其差異具有統(tǒng)計(jì)學(xué)意義。結(jié)核病史:合并效應(yīng)量OR值為6.24,95%CI(2.81,13.85),P0.05,其差異具有統(tǒng)計(jì)學(xué)意義。結(jié)論:本研究對(duì)TFI臨床上常見(jiàn)中醫(yī)證型及主要危險(xiǎn)因素進(jìn)行了統(tǒng)計(jì)分析,分析結(jié)果為:TFI的中醫(yī)證型分布以氣滯血瘀型、腎虛血瘀型、濕熱瘀組型為主,其中氣滯血瘀型占53.5%、腎虛血瘀型占18.5%、濕熱瘀組型占17.3%。TFI相關(guān)危險(xiǎn)因素分別為:盆腔炎病史,闌尾炎史,初次性生活年齡20歲,異位妊娠史,NG/CT/UU感染史,結(jié)核病史,其聯(lián)系強(qiáng)度由強(qiáng)到弱為:異位妊娠史,NG/CT/UU感染史,結(jié)核病史,盆腔炎病史,初次性生活年齡20歲,闌尾炎史。而人工流產(chǎn)并不是引起TFI的危險(xiǎn)因素。
[Abstract]:Objective: to find out the common TCM syndromes of tubal factor infertility syndrome and related risk factors published at home and abroad in recent 15 years. Meta-analysis was used to evaluate the common clinical risk factors and the associated strength of TFI in order to provide evidence-based basis for early prediction of TFI and to improve our understanding of the disease and the level of diagnosis and treatment. Methods: the database CNKI, Wanfang and Weip were searched by Pubmedus Cochranege sci database, and the books and magazines on TFI of Henan Institute of traditional Chinese Medicine library after 2000 were searched by hand, and the references included in the literature were screened and searched. According to the inclusion criteria and exclusion criteria, the retrieved documents were classified and screened, and the information extraction and statistical analysis were carried out based on the information points of TCM syndromes and related risk factors. Results: five articles about TCM syndromes of TFI were included. The results were as follows: qi stagnation and blood stasis type, kidney deficiency and blood stasis type, dampness and heat stasis type were the main types of TCM syndromes. Qi stagnation and blood stasis type accounted for 53.5%, kidney deficiency and blood stasis type accounted for 18.5%, dampness and heat stasis type accounted for 17.3%. A total of 7 articles on TFI-related risk factors were included. The results of meta-analysis were as follows: the history of pelvic inflammatory disease: the OR value of combined effect was 5.44 鹵95 and the difference was statistically significant. The history of induced abortion: the OR value of the combined effect was 1.3095 CI 0.981.74 P0.05.The difference was not statistically significant. History of appendicitis: the OR value of the combined effect was 3.23 ~ 95CI1.646.35 / P0.05.The difference was statistically significant. The age of the first sexual life was 20 years old: the OR value of the combined effect was 3.46% 95% and 2.115.68% P0.05.The difference was statistically significant. History of ectopic pregnancy: the OR value of the combined effect was 7.80 / 95CII 3.82 / 15.93 / P 0.05, the difference was statistically significant. The history of CTU infection was statistically significant. The OR value of the combined effect was 6.68 / 95 / CI 3.69 / 12.11 / P0.05, and the difference was statistically significant. History of tuberculosis: OR value of combined effect was 6.24% 95% (P 0.05), and the difference was statistically significant. Conclusion: the common TCM syndromes and main risk factors of TFI were statistically analyzed. The results showed that the TCM syndromes of 10 TFI were mainly qi stagnation and blood stasis type, kidney deficiency and blood stasis type, damp-heat and blood stasis type. Among them, Qi stagnation and blood stasis type accounted for 53.5%, kidney deficiency and blood stasis type accounted for 18.5, damp-heat stasis group type accounted for 17.3.TFI related risk factors were: history of pelvic inflammation, history of appendicitis, age of first sexual life 20 years old, history of ectopic pregnancy and history of NGP / CTUU infection, history of tuberculosis. The connection intensity from strong to weak is: history of ectopic pregnancy, history of NGP CT-UU infection, history of tuberculosis, history of pelvic inflammation, first sexual life age of 20 years, history of appendicitis. Abortion is not a risk factor for TFI.
【學(xué)位授予單位】：河南中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R271.14

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