本文選題：針刺療法　切入點(diǎn)：類風(fēng)濕性關(guān)節(jié)炎　出處：《中南大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年05期 　論文類型：期刊論文

【摘要】：目的:探究針刺對(duì)患有類風(fēng)濕性關(guān)節(jié)炎大耳白兔的鎮(zhèn)痛時(shí)效及其中樞作用機(jī)制。方法:將60只大耳白兔隨機(jī)分為正常組(n=6)、模型組(n=6)、體針組(n=24)和頰針組(n=24),再將后兩組分為針后即時(shí)(0 h)、針后0.5,1,2 h 4個(gè)亞組,每組各6只。白兔類風(fēng)濕性關(guān)節(jié)炎模型采用卵蛋白誘導(dǎo)建立。體針組針刺雙側(cè)"膝眼"和"足三里"1次,頰針組雙側(cè)頰針針刺"膝"1次,行針15 s,留針30 min。采用PL-200熱刺痛儀檢測(cè)痛閾,以兔出現(xiàn)縮耳掙扎動(dòng)作為疼痛反應(yīng)指標(biāo),自照射開(kāi)始至兔出現(xiàn)反應(yīng)的潛伏期時(shí)間作為該兔的痛閾值;使用放射免疫法檢測(cè)兔腦脊液中β-內(nèi)啡肽(β-endorplhin,β-EP)及八肽膽囊收縮素(cholecystokinin-8,CCK-8)含量。結(jié)果:與正常組相比,模型組痛閾和CCK-8含量顯著降低(P0.01),β-EP含量顯著升高(P0.05);與模型組相比,體針組和頰針組的痛閾在0和1 h(P0.05或P0.01)顯著升高;體針組和頰針組兔腦脊液中CCK-8和β-EP含量均顯著高于模型組(P0.01或P0.05);頰針組的即時(shí)(0 h)CCK-8和β-EP含量顯著高于體針組(P0.05),其他時(shí)間無(wú)明顯變化。結(jié)論:針刺治療可以有效緩解類風(fēng)濕性關(guān)節(jié)炎的疼痛,頰針療法的即時(shí)鎮(zhèn)痛效應(yīng)優(yōu)于體針治療,且這種即時(shí)鎮(zhèn)痛效應(yīng)與腦脊液中β-EP和CCK-8含量變化相關(guān)。
[Abstract]:Objective: to explore the analgesic effect and central mechanism of acupuncture on rabbits with rheumatoid arthritis. Methods: 60 rabbits were randomly divided into normal group, model group and buccal acupuncture group. The group was divided into 4 subgroups, one hour after acupuncture and one hour after acupuncture, and four subgroups were divided into 4 groups. There were 6 rabbits in each group. The rabbit model of rheumatoid arthritis was induced by ovalbumin. The body acupuncture group needled the bilateral "knee eyes" and "Zusanli" once, and the buccal acupuncture group the bilateral buccal acupuncture "knee" once. The pain threshold was measured by PL-200 thermal tingling instrument. The pain threshold was determined by the pain response index of the rabbit's ear contraction and struggling, and the latency period from the beginning of irradiation to the rabbit's reaction time was used as the pain threshold. The contents of 尾 -endorphin (尾 -EP) and cholecystokinin-8 (CCK-8) in cerebrospinal fluid of rabbits were measured by radioimmunoassay. Results: compared with the normal group, the pain threshold and CCK-8 content in the model group were significantly lower than those in the normal group, and the content of 尾 -EP was significantly higher than that in the model group. The pain threshold of body acupuncture group and buccal acupuncture group increased significantly at 0 and 1 h (P0.05 or P0.01). The contents of CCK-8 and 尾 -EP in cerebrospinal fluid of rabbits in body acupuncture group and buccal acupuncture group were significantly higher than those in model group (P0.01 or P0.05), and the contents of CCK-8 and 尾 -EP in buccal acupuncture group were significantly higher than those in body acupuncture group at 0 h. The pain of rheumatoid arthritis, The immediate analgesic effect of buccal acupuncture was better than that of body acupuncture, and the immediate analgesic effect was related to the changes of 尾 -EP and CCK-8 in cerebrospinal fluid.
【作者單位】： 甘肅中醫(yī)藥大學(xué)針灸推拿學(xué)院;天水市中醫(yī)醫(yī)院針灸科;
【基金】：國(guó)家自然科學(xué)基金(81260559)~~
【分類號(hào)】：R245

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