PART 1 GSTM1 and GSTT1 Genetic Susceptibility and Interaction with Chemical Exposures in Childhood Acute Lymphoblastic Leukemia: A Systematic Review and Meta-analysisBackground: The glutathione s-transferase genes play an important role in the detoxification of carcinogenic substances,and null mutations of these genes are linked to increase in acute lymphoblastic leukemia(ALL)due to an increase in susceptibility to environmental exposures of toxins and carcinogens,and chemical exposures like toba...

【文章頁數(shù)】：90 頁

【學(xué)位級別】：碩士

【文章目錄】：
ABSTRACT
LIST OF ABBREVIATIONS
PART 1
    INTRODUCTION
    METHODS AND MATERIALS
    RESULTS
    DISCLUSION
    CONCLUSION
    REFERENCES
PART 2
    INTRODUCTION
    MATERIALS AND METHODS
        Study area
        Study design
        Source population
        Population sample and size
        Sampling technique
        Inclusion and exclusion criteria
        Data collection method
        Translation Procedure
        Data analysis
        Dissemination of findings
        Ethical consideration
        Study variables
    RESULTS
    DISCUSSION
    LIMITATIONS
    CONCLUSION
    LITERATURE REVIEW
        Acute Lymphoblastic Leukemia in Children
            Definition
            Classification of Childhood ALL
            Infectious Etiology
        Genetic Susceptibility
        Xenobiotic Metabolism
        Vulnerability to Environmental Exposures
        Principles of Treatment
        Management of Relapse
        Background of Henan Province
REFERENCES
ACKNOWLEDGEMENTS
APPENDIX



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