發(fā)布時(shí)間：2019-01-18 08:27

【摘要】：背景與目的已有的研究表明:在多種惡性腫瘤中發(fā)現(xiàn)轉(zhuǎn)移相關(guān)蛋白1(metastasis associated protein1,MTA1)發(fā)揮著促進(jìn)腫瘤侵襲與轉(zhuǎn)移的作用,且與腫瘤患者預(yù)后不佳有關(guān)。目前MTA1在肺癌中的預(yù)后作用仍有爭議,故我們采用meta分析的方法評(píng)估其在肺癌患者中的預(yù)后價(jià)值。方法通過計(jì)算機(jī)檢索PubMed、Embase、萬方數(shù)據(jù)庫、中國生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫、中國知網(wǎng)等數(shù)據(jù)庫,收集納入研究MTA1表達(dá)與肺癌預(yù)后關(guān)系的文獻(xiàn)及相關(guān)數(shù)據(jù),采用Stata 12.0軟件進(jìn)行數(shù)據(jù)分析,合并值為風(fēng)險(xiǎn)比(hazard ratio,HR)。結(jié)果總共納入8項(xiàng)研究共712例中國肺癌患者,對(duì)這些研究進(jìn)行異質(zhì)性檢驗(yàn),發(fā)現(xiàn)存在異質(zhì)性(I~2=59.0%,P=0.017),故采用隨機(jī)效應(yīng)模型進(jìn)行數(shù)據(jù)合并得HR=2.07(95%CI:1.42-3.02,P0.001)。同時(shí)分層分析顯示在非小細(xì)胞肺癌(non-small cell lung cancer,NSCLC)中各研究無明顯異質(zhì)性(I~2=47.0%,P=0.093),采用固定效應(yīng)模型合并得HR=1.66(95%CI:1.27-2.18,P0.001)。結(jié)論 MTA1高表達(dá)可能是中國NSCLC患者預(yù)后不良的一個(gè)指標(biāo),在肺癌及小細(xì)胞肺癌中的預(yù)后價(jià)值尚缺乏證據(jù)。
[Abstract]:Background & AIM previous studies have shown that metastasis associated protein 1 (metastasis associated protein1,MTA1) plays a role in promoting tumor invasion and metastasis in various malignant tumors and is related to poor prognosis of tumor patients. At present, the prognostic role of MTA1 in lung cancer is still controversial, so we use the method of meta analysis to evaluate its prognostic value in patients with lung cancer. Methods PubMed,Embase, Wanfang database, Chinese biomedical literature database and China knowledge network database were searched by computer to collect the literature and related data about the relationship between the expression of MTA1 and the prognosis of lung cancer. Stata 12.0 software was used to analyze the data, and the combined value was risk ratio (hazard ratio,HR). Results A total of 712 patients with lung cancer in China were enrolled in 8 studies. The heterogeneity of these studies was tested and heterogeneity was found. Therefore, the random effect model is used to combine the data to obtain HR=2.07 (95 CI: 1.42-3.02 P0.001). At the same time, stratification analysis showed that there was no significant heterogeneity in all studies of non-small cell lung cancer (non-small cell lung cancer,NSCLC). The fixed effect model was used to combine HR=1.66 (95 CI: 1.27-2.18). P0.001) Conclusion the high expression of MTA1 may be an indicator of poor prognosis in patients with NSCLC in China, and the prognostic value in patients with lung cancer and small cell lung cancer is still lack of evidence.
【作者單位】： 南京醫(yī)科大學(xué)附屬南京醫(yī)院呼吸科;
【基金】：江蘇省臨床醫(yī)學(xué)科技專項(xiàng)(No.BE2015611)資助~~
【分類號(hào)】：R734.2

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