發(fā)布時間：2018-07-25 09:13

【摘要】：目的檢測丙酮酸脫氫酶激酶4(pyruvate dehydrogenase kinase 4,PDK4)在結腸癌組織及癌旁黏膜組織中的表達情況,初步探討其臨床意義。方法應用組織芯片技術結合免疫組織化學染色方法,檢測本院收治的172例結腸癌患者術后組織標本及86例癌旁腸黏膜組織中PDK4蛋白的表達,對結果及臨床病理學參數進行統(tǒng)計學分析。結果 PDK4在172例結腸癌組織中高表達率顯著高于86例癌旁腸黏膜組織(57.0%vs 26.7%,P0.01),PDK4蛋白表達高低與結腸癌的分化程度、臨床分期、淋巴結轉移、預后等密切相關(P0.05),且PDK4高表達組患者的生存時間顯著低于低表達組患者(P0.01)。在臨床分期低的結腸癌患者中,PDK高表達者預后較差(P0.01);而在臨床分期高的結腸癌患者中,PDK表達高低預后差異無統(tǒng)計學意義。結論 PDK4蛋白在結腸癌組織中表達高于癌旁腸黏膜組織,其可能參與結腸癌的發(fā)生、發(fā)展。
[Abstract]:Objective to detect the expression of pyruvate dehydrogenase kinase 4 (PDK4) in colon cancer tissues and adjacent mucosa, and to explore its clinical significance. Methods tissue microarray technique and immunohistochemical staining were used to detect the expression of PDK4 protein in the tissues of 172 patients with colon cancer and 86 patients with adjacent intestinal mucosa. The results and clinicopathological parameters were analyzed statistically. Results the high expression rate of PDK4 in 172 cases of colon cancer was significantly higher than that in 86 cases of adjacent intestinal mucosa (57.0%vs 26.7), and the expression of PDK4 protein was significantly higher than that in the adjacent mucosa of colon cancer (P0.01) and the degree of differentiation, clinical stage and lymph node metastasis of colon cancer. Prognosis was closely related (P0.05), and the survival time of patients with high expression of PDK4 was significantly lower than that of patients with low expression (P0.01). The prognosis of patients with high expression of PDK was poor in patients with low clinical stage (P0.01), but there was no significant difference in the prognosis of PDK expression in patients with high clinical stage (P0.01). Conclusion the expression of PDK4 protein in colon cancer tissues is higher than that in adjacent mucosa tissues, which may be involved in the occurrence and development of colon cancer.
【作者單位】： 第三軍醫(yī)大學西南醫(yī)院腫瘤科;
【基金】：國家自然科學基金面上項目(81272364)~~
【分類號】：R735.35

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