本文選題：上尿路尿路上皮腫瘤 + 輸尿管鏡檢查�。� 參考：《第三軍醫(yī)大學(xué)學(xué)報(bào)》2017年01期

【摘要】：目的 Meta分析上尿路尿路上皮腫瘤(upper tract urothelial carcinoma,UTUC)根治手術(shù)前行輸尿管鏡檢查(ureteroscopy,URS)對(duì)UTUC遠(yuǎn)期預(yù)后的影響。方法計(jì)算機(jī)檢索Pub Med、EMbase、Cochrane Library、中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)、萬(wàn)方、維普和中國(guó)知網(wǎng)數(shù)據(jù)庫(kù),收集URS對(duì)UTUC預(yù)后影響的前瞻性或回顧性研究,檢索時(shí)限為建庫(kù)至2016年2月29日。由兩名研究者按照納入與排除標(biāo)準(zhǔn)進(jìn)行文獻(xiàn)納入,對(duì)納入的研究行質(zhì)量評(píng)價(jià),提取相關(guān)腫瘤預(yù)后資料風(fēng)險(xiǎn)比(hazard ratios,HR)及其95%可信區(qū)間(confidence interval,CI),采用Stata 12軟件進(jìn)行Meta分析。結(jié)果共納入13個(gè)回顧性研究,包括4 105例患者。Meta分析結(jié)果顯示:術(shù)前行URS未增加疾病無(wú)復(fù)發(fā)生存風(fēng)險(xiǎn),單因素合并結(jié)果[HR=0.93,95%CI(0.73,1.13)],多因素合并結(jié)果[HR=1.13,95%CI(0.90,1.36)];行URS未增加膀胱內(nèi)無(wú)復(fù)發(fā)生存風(fēng)險(xiǎn),單因素合并結(jié)果[HR=1.13,95%CI(0.82,1.43)],多因素合并結(jié)果[HR=1.54,95%CI(0.97,2.12)];對(duì)于腫瘤特異生存期,單因素合并結(jié)果顯示行URS組優(yōu)于未行URS組[HR=0.68,95%CI(0.48,0.88)],而多因素合并結(jié)果兩者差異無(wú)統(tǒng)計(jì)學(xué)意義[HR=0.83,95%CI(0.54,1.12)];行URS未增加總體生存風(fēng)險(xiǎn),單因素合并結(jié)果差異無(wú)統(tǒng)計(jì)學(xué)意義[HR=0.87,95%CI(0.46,1.27)]。結(jié)論術(shù)前行URS并未影響UTUC患者術(shù)后遠(yuǎn)期腫瘤復(fù)發(fā)及生存情況。
[Abstract]:Objective to analyze the effect of ureteroscopy on the long term prognosis of upper urinary tract epithelial tumor (UTUC) by ureteroscope before radical operation with upper tract urothelial carcinoma (UTUC) by Meta. Methods Pub Medsite EMbase Cochrane Library, Chinese Biomedical Literature Database, Wanfang, Weip and China KnowledgeNet databases were searched by computer. Prospective or retrospective studies on the influence of URS on the prognosis of UTUC were collected. The search time was established until February 29, 2016. According to the criteria of inclusion and exclusion, two researchers carried out literature review, evaluated the quality of the included studies, extracted the risk ratio of tumor prognostic data to Hazard ratios-HRs and 95% confidence interval-CIG, and analyzed Meta by Stata 12 software. Results A total of 13 retrospective studies were included, including 4,105 patients. Meta-analysis results showed that preoperative URS did not increase the risk of disease recurrence, univariate association [HRN 0.9395 CI0.73C1.13], multivariate results [HR1.13995 CI0.901.36], and URS did not increase the risk of intravesical recurrence. Results of univariate combination [HRN 1.1395 CI 0.821.43], multivariate combination results [HRN 1.5495 CI 0.97 / 2.12]; for tumor-specific survival period, univariate combination results showed that URS group was superior to non-URS group [HR0.6895 CI 0.480.88], but multifactorial combination had no statistical significance [HRN 0.8395CI 0.541.12]; URS did not increase the overall survival risk. There was no significant difference in univariate combined results. Conclusion preoperative URS does not affect the recurrence and survival of long-term tumor in patients with UTUC.
【作者單位】： 蘭州大學(xué)泌尿外科研究所蘭州大學(xué)第二醫(yī)院泌尿外科甘肅省泌尿系統(tǒng)疾病臨床醫(yī)學(xué)中心甘肅省泌尿系統(tǒng)疾病研究重點(diǎn)實(shí)驗(yàn)室;
【基金】：國(guó)家自然科學(xué)基金面上項(xiàng)目(81402122)~~
【分類號(hào)】：R737.1

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 李麗卿，，范明卿;輸尿管鏡檢查與取石術(shù)的配合[J];福建醫(yī)藥雜志;1995年03期

2 劉遇春;熊世華;劉代中;劉登;楊研;;輸尿管鏡檢查及治療的常見并發(fā)癥處理[J];現(xiàn)代醫(yī)藥衛(wèi)生;2008年15期

3 吳克讓;;輸尿管鏡檢查[J];國(guó)外醫(yī)學(xué).外科學(xué)分冊(cè);1988年05期

4 凌桂明;硬質(zhì)塑料橄欖頭擴(kuò)張導(dǎo)管在輸尿管鏡檢查中的應(yīng)用[J];上海醫(yī)學(xué);1997年03期

5 劉雪發(fā);;順行輸尿管鏡檢查取出結(jié)石[J];國(guó)外醫(yī)學(xué).泌尿系統(tǒng)分冊(cè);1986年05期

6 阮旭晴;;小兒輸尿管鏡檢查[J];國(guó)外醫(yī)學(xué).泌尿系統(tǒng)分冊(cè);1991年03期

7 詹河涓,鄭彬,陳曉峰,李德超;表麻下行輸尿管鏡檢查和治療23例報(bào)告[J];現(xiàn)代泌尿外科雜志;2002年01期

8 文瀚東,潘鐵軍,李志強(qiáng),沈國(guó)球,劉志敏;間苯三酚注射液在輸尿管鏡檢查中的應(yīng)用[J];中國(guó)藥師;2005年03期

9 ;尿的成分異常[J];國(guó)外科技資料目錄.醫(yī)藥衛(wèi)生;1999年09期

10 謝衡生,馮華國(guó);輸尿管鏡檢查并發(fā)急性腎功能衰竭一例[J];醫(yī)學(xué)臨床研究;2004年08期

本文編號(hào)：1942569