本文選題：脈沖電場(chǎng)(PEF) + 跨膜電位��； 參考：《生物化學(xué)與生物物理進(jìn)展》2017年01期

【摘要】：基于多層電介質(zhì)模型,對(duì)于適應(yīng)于球形生物細(xì)胞的脈沖電場(chǎng),提出了一種等效電路模型,在相同頻域下,內(nèi)膜和外膜的變化趨勢(shì)相同,頻域分析表明,不同頻譜場(chǎng)將引起不同的生物醫(yī)學(xué)效應(yīng).我們針對(duì)癌癥細(xì)胞計(jì)算了跨膜電壓,并討論了脈沖和跨膜電壓以及阻抗的關(guān)系.結(jié)果表明不同的頻域和不同的持續(xù)時(shí)間對(duì)細(xì)胞的內(nèi)膜和外膜有選擇性的影響,時(shí)域和頻域的分析顯示,在細(xì)胞上有一個(gè)窗口,當(dāng)持續(xù)時(shí)間在10~(-8)~10~(-6)s之間,細(xì)胞內(nèi)膜的電壓將高于細(xì)胞外膜的電壓.窗口效應(yīng)為解釋生物細(xì)胞的脈沖電學(xué)效應(yīng)提供了一種參考思路.
[Abstract]:Based on the multilayer dielectric model, an equivalent circuit model is proposed for the pulsed electric field suitable for spherical biological cells. In the same frequency domain, the change trend of the inner membrane and the outer membrane is the same, and the frequency domain analysis shows that,Different spectrum fields will cause different biomedical effects.We calculate the transmembrane voltage for cancer cells and discuss the relationship between pulse and transmembrane voltage and impedance.The results showed that different frequency domain and different duration had a selective effect on the intima and outer membrane of the cell. The analysis of time domain and frequency domain showed that there was a window in the cell, when the duration was between 10 ~ 10 ~ (-8) ~ 10 ~ (-6) s.The voltage of the inner membrane will be higher than that of the outer membrane.Window effect provides a reference for explaining the pulse electrical effect of biological cells.
【作者單位】： 電子科技大學(xué)物理電子學(xué)院;
【基金】：supported by grants from The National Natural Science Foundation of China(31470822) the Teaching and Research Project of UESTC(Y0309402370109068)~~
【分類(lèi)號(hào)】：R730.2

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本文編號(hào)：1747299