【摘要】：目的:自制伏立康唑磺丁基醚-β-環(huán)糊精包合物與注射用伏立康唑(VFEND~汶)大鼠體內(nèi)藥動(dòng)學(xué)對(duì)比研究。方法:以VFEND~汶為對(duì)照,Wistar大鼠為受試動(dòng)物,采用超高效液相-飛行時(shí)間質(zhì)譜(U-HPLC/Q-TOF-MS)監(jiān)測伏立康唑的血藥濃度,計(jì)算藥動(dòng)學(xué)參數(shù),對(duì)自制藥與對(duì)照藥的各藥動(dòng)參數(shù)進(jìn)行獨(dú)立樣本雙側(cè)t檢驗(yàn)。結(jié)果:自制藥和對(duì)照藥大鼠體內(nèi)伏立康唑的消除半衰期(t1/2)分別為(2.099±0.202)h和(2.142±0.163)h,藥物濃度-時(shí)間曲線下面積(AUC0-12)分別為(23.247±1.264)μg·h·mL~(-1)和(22.748±1.568)μg·h·mL~(-1)。結(jié)論:自制藥與對(duì)照藥的大鼠體內(nèi)藥動(dòng)學(xué)行為相似,各藥動(dòng)學(xué)參數(shù)相近。
[Abstract]:Aim: to compare the pharmacokinetics of Voliconazole sulfonbutyl ether-尾-cyclodextrin inclusion complex and Voliconazole (VFEND~ Wen) rats for injection. Methods: VFEND~ and Wistar rats were used as control and Wistar rats as subjects. The blood concentration of Voliconazole was monitored by ultra-high performance liquid phase-time-of-flight mass spectrometry (U-HPLC/Q-TOF-MS). The pharmacokinetics parameters were calculated and the pharmacokinetics parameters of Vriconazole were tested by bilateral t-test of independent samples. Results: the elimination half-life (T1 鈮，

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