【摘要】：目的口服抗凝藥物(OAC)聯(lián)合應用香豆素、新抗凝劑治療血栓栓塞并發(fā)癥的效果非常顯著。然而,有研究表明,治療中經常會出現抗凝劑使用過量或用量不足。本文探討長期服用OAC患者的正確治療方法,并根據整群隨機PICANT試驗的篩查結果,對此類患者的相關特點進行總結。方法在德國黑森州隨機選取全科診所,由研究成員進行到訪研究。使用全科醫(yī)生軟件,以預先設定指令生成匿名患者名單,以該匿名名單對符合條件的患者進行調查。符合條件的患者被分為3組,A組為具有長期使用OAC指征且正服用抗凝劑的患者;B組為具有長期使用OAC指征但未服用抗凝劑的患者;C組為不具有長期服用OAC指征但長期服用抗凝劑的患者。采用SPSS 20.0軟件進行描述性統(tǒng)計分析。結果 52家全科診所納入2 036例符合條件的患者,其中,275例患者因無法歸類而被排除。最終納入研究的患者1 761例,其中,A組1 641例,B組78例,C組42例。獲取1 504例患者的國際標準化比值(INR),其中1 013例患者的INR處在治療區(qū)間。全科醫(yī)生軟件評估發(fā)現,大部分患者具有良好的治療依從性,6.1%的患者服用了新型抗凝劑。結論大部分患者的抗凝療法正確,應長期使用OAC但未服用抗凝劑的患者和不應長期使用OAC但長期服用抗凝劑的患者低于預期,OAC的控制效果在合理高值范圍內。
[Abstract]:Objective to treat the complications of thrombus embolism with oral anticoagulant (OAC) combined with coumarin. However, studies have shown that anticoagulant is often overused or insufficient in treatment. In this paper, the correct treatment of patients taking OAC for a long time was discussed, and the related characteristics of these patients were summarized according to the screening results of cluster random PICANT test. Methods the general clinic was randomly selected in Hesse, Germany, and the research members were visited. Use the general practitioner software to generate a list of anonymous patients with predetermined instructions, and use the anonymous list to investigate eligible patients. The eligible patients were divided into three groups: group A (patients with long-term use of OAC indication and taking anticoagulant), group B (patients with long-term use of OAC indication but not anticoagulant) and group C (patients who did not have long-term OAC indication but took anticoagulant for a long time). Descriptive statistical analysis was carried out with SPSS 20.0 software. Results 2036 eligible patients were included in 52 general practice clinics, of which 275 patients were excluded because they could not be classified. Finally, 1761 cases were included in the study, including 1641 cases in group A, 78 cases in group B and 42 cases in group C. The international standardized ratio (INR),) of 1 504 patients was obtained. The INR of 1 013 patients was in the treatment range. General practitioners software evaluation found that most patients had good treatment compliance, 6.1% of patients took new anticoagulant. Conclusion the anticoagulant therapy of most patients is correct. The patients who should use OAC for a long time but not take anticoagulant for a long time and those who should not use OAC for a long time but take anticoagulant for a long time are lower than expected. The control effect of OAC is within a reasonable and high range.
【分類號】：R96

【相似文獻】

相關期刊論文 前10條

1 王亞軍，，李燁;日產化學工業(yè)和綠十字公司的新型口服血小板抗凝劑[J];藥學進展;1994年04期

2 Walker ID,Machin S,Baglin TP,吳淑燕,王兆鉞;口服抗凝劑指南(第三版)[J];國外醫(yī)學.輸血及血液學分冊;2004年06期

3 徐革;劉洪學;;抗凝劑對酶活性的影響[J];四川省衛(wèi)生管理干部學院學報;2007年03期

4 王擁軍;;卷首語[J];中國新藥雜志;2012年11期

5 韓秀霞;;口服抗凝劑[J];國外醫(yī)學情報;1998年05期

6 王曉東;劉興會;;抗凝劑的種類及其在妊娠中的應用[J];中國實用婦科與產科雜志;2006年03期

7 藤井彰;李森;;阿斯匹林作抗凝劑使用時應小劑量緩慢給藥[J];黑龍江醫(yī)藥科學;1987年03期

8 李蓉;喬杰;;抗凝劑在生殖領域中的應用[J];中國實用婦科與產科雜志;2006年03期

9 張心聲;血漿和枸椽酸鈉抗凝劑中鋁的含量[J];國外醫(yī)學.輸血及血液學分冊;1992年05期

10 吳立志,陳槐卿,鄧力;抗凝劑、溫度和性別對體外中性粒細胞自發(fā)性激活的影響[J];生物醫(yī)學工程學雜志;1999年03期

相關會議論文 前1條

1 陳穎;侯建明;陳國龍;林豪;林洪鏗;褚曉凌;曾嘉;陳岑;林娟;Markus Dettke;;鈣劑補充減輕檸檬酸鹽抗凝劑對獻血者骨代謝的影響[A];中國輸血協(xié)會第五屆輸血大會論文專集（摘要篇）[C];2010年

相關重要報紙文章 前1條

1 國訊;多個國家警示新型口服抗凝劑的出血風險[N];中國醫(yī)藥報;2013年

本文編號：2502204