【摘要】：目的:為補(bǔ)充和完善我國基本藥物遴選方法提供參考。方法:針對基本藥物遴選的要求,運(yùn)用背包理論,結(jié)合實(shí)際情況確定基本藥物遴選的目標(biāo)函數(shù)和約束條件,進(jìn)行基本藥物遴選模型的構(gòu)建,并通過實(shí)例分析所建模型的可行性。結(jié)果:所構(gòu)建的模型目標(biāo)函數(shù)為所遴選基本藥物組合的成本最小值,即Min∑C_jX_j,其他還包括藥品的疾病覆蓋、藥品不良反應(yīng)、禁忌、注意事項(xiàng)、劑型、規(guī)格6個(gè)方面的約束條件。以9種常見的口服降糖藥作為待選藥品,應(yīng)用該模型選出的降糖類基本藥物為格列吡嗪、格列齊特、二甲雙胍和瑞格列奈。結(jié)論:本研究構(gòu)建的基于背包理論的基本藥物遴選模型較為科學(xué)、客觀,有很強(qiáng)的實(shí)用性。
[Abstract]:Objective: to provide reference for replenishing and perfecting the selection method of essential drugs in China. Methods: according to the requirements of essential drug selection, the objective function and constraint conditions of essential drug selection were determined by using backpack theory and the objective function and constraint conditions of essential drug selection were determined according to the actual situation, and the feasibility of the model was analyzed by an example. Results: the objective function of the model was the minimum cost of the selected basic drug combination, that is, the other constraints, such as disease coverage, adverse drug reactions, taboos, matters needing attention, dosage form and specification, were also included in the drug coverage, adverse drug reactions, taboos, dosage forms and specifications. Nine common oral hypoglycemic drugs were used as selected drugs, and the essential hypoglycemic drugs selected by the model were glipizide, gliclazide, metformin and repaglinide. Conclusion: the basic drug selection model based on knapsack theory is scientific, objective and practical.
【作者單位】： 沈陽藥科大學(xué)工商管理學(xué)院 哈爾濱工業(yè)大學(xué)科軟股份有限公司
【基金】：遼寧省教育廳項(xiàng)目(No.201610163W01) 遼寧省科學(xué)技術(shù)計(jì)劃項(xiàng)目(No.2012225095)
【分類號(hào)】：R95

【參考文獻(xiàn)】

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