發(fā)布時間：2019-03-16 09:23

【摘要】：目的制備二乙酰大黃酸固體分散體,提高其體外溶出性能。方法以聚乙烯吡咯烷酮k30(PVP k30)和泊洛沙姆188(Poloxamer188)為輔料載體,采用研磨法制備二乙酰大黃酸固體分散體,紅外測定法和差示掃描量熱法對固體分散體進行結(jié)構(gòu)分析。結(jié)果二乙酰大黃酸∶PVP k30∶Poloxamer188的最佳比例為2∶1∶1,該條件下制備二乙酰大黃酸固體分散體時,其體外溶出度在30 min達到了90%。差示掃描量熱法顯示,藥物與輔料形成共聚物;紅外分析顯示,二乙酰大黃酸與兩種輔料未形成氫鍵,結(jié)構(gòu)未發(fā)生變化。結(jié)論以PVP k30和Poloxamer188為載體制備的固體分散體能夠顯著提高二乙酰大黃酸的體外溶出度。
[Abstract]:Objective to prepare diacetyl Rhein solid dispersion and improve its dissolution performance in vitro. Methods using polyvinylpyrrolidone k30 (PVP k30) and Poloxamer 188 (Poloxamer188) as excipients, the solid dispersion of diacetyl Rhein was prepared by grinding method. The structure of solid dispersion was analyzed by IR and differential scanning calorimetry (DSC). Results the optimal ratio of diacetyl Rhein to PVP k30:Poloxamer188 was 2? 1? 1?. When the solid dispersion of diacetyl Rhein was prepared under this condition, the in vitro dissolution of diacetyl Rhein reached 90% at 30 min. Differential scanning calorimetry (DSC) showed that the drug formed a copolymer with the excipients, and the infrared analysis showed that the diacetyl Rhein acid did not form hydrogen bond with the two excipients, and the structure did not change. Conclusion solid dispersion based on PVP-k30 and Poloxamer188 can significantly improve the dissolution of diacetyl Rhein in vitro.
【作者單位】： 貴州醫(yī)科大學藥學院;
【基金】：貴陽市科技計劃項目([2013204]4-4) 2014年貴州省教育廳大學生創(chuàng)新創(chuàng)業(yè)(培育)項目(201410660029)
【分類號】：R943

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