【摘要】：口服液體制劑中苦味藥物多以分子態(tài)或膠體形式存在,分散度大,能瞬時形成廣泛而強烈的刺激,使得傳統(tǒng)掩味與矯味方法難以完全掩蔽苦味,嚴重制約患者服用的順應(yīng)性。近年來,小分子苦味淬滅劑的發(fā)現(xiàn),為改善口服液體制劑的口感提供了新的選擇,逐漸成為掩味技術(shù)研究的熱點�；诖�,筆者闡釋了小分子苦味淬滅劑的概念與特點,歸納了苦味淬滅的作用機制與影響因素,介紹了常用的小分子苦味淬滅劑及其特點和應(yīng)用,以期推動小分子苦味淬滅劑在口服液體制劑中的開發(fā)應(yīng)用,為口服液體制劑的苦味掩蔽提供科學(xué)的理論指導(dǎo)與技術(shù)支持,對于推動口服液體制劑現(xiàn)實問題的解決、處方設(shè)計優(yōu)化與產(chǎn)品品質(zhì)提升具有重要理論價值與實踐意義。
[Abstract]:The bitter drugs in oral liquid are mostly in the form of molecular state or colloid, with high dispersion, which can form extensive and strong stimuli instantly, which makes it difficult for the traditional methods of masking and correcting taste to completely mask the bitter taste and seriously restrict the compliance of patients. In recent years, the discovery of small molecular bitter quenching agent has provided a new choice for improving the taste of oral liquid body preparation, and has gradually become a hot spot in the study of taste masking technology. Based on this, the author explained the concept and characteristics of the small molecular bitter flavor quenching agent, summarized the mechanism and influencing factors of the bitter flavor quenching, introduced the commonly used small molecule bitter flavor quenching agent and its characteristics and applications. In order to promote the development and application of small molecule bitter quenching agent in oral liquid body preparation, to provide scientific theoretical guidance and technical support for the bitter taste masking of oral liquid body preparation, and to solve the practical problems of oral liquid body preparation. The optimization of prescription design and the improvement of product quality have important theoretical value and practical significance.
【作者單位】： 成都中醫(yī)藥大學(xué)藥學(xué)院中藥材標(biāo)準(zhǔn)化教育部重點實驗室中藥資源系統(tǒng)研究與開發(fā)利用省部共建國家重點實驗室培育基地;成都中醫(yī)藥大學(xué)附屬醫(yī)院中心實驗室;江西中醫(yī)藥大學(xué);
【基金】：國家自然科學(xué)基金資助項目(81403115) 國家基礎(chǔ)科學(xué)人才培養(yǎng)基金資助項目(J13100340-19)
【分類號】：R943

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本文編號：2386466