【摘要】：目的建立頂空毛細管柱氣相色譜法測定帕利哌酮中的溶劑殘留量。方法以Agilent DB-624(30 m×530μm,3μm)柱為色譜柱,以氮氣為載氣,以氫火焰離子化檢測器檢測,以N,N-二甲基乙酰胺為溶劑,采用程序升溫模式檢測帕利哌酮原料藥中甲醇、乙酸乙酯、二氯甲烷和三乙胺的殘留量。結果 4種揮發(fā)性有機溶劑均達到基線分離,在考察的質量濃度內線性良好(r≥0.999 0),平均回收率分別為103.1%、101.9%、101.3%和100.8%,RSD分別為2.9%、2.8%、3.3%和6.2%(n=9)。結論該方法操作簡單、快速、靈敏、可靠,可用于帕利哌酮原料藥中4種有機溶劑殘留量測定。
[Abstract]:Objective to establish a headspace capillary gas chromatographic method for the determination of solvent residues in peridol. Methods Agilent DB-624 (30 m 脳 530 渭 m) column was used as chromatographic column, nitrogen as carrier gas, hydrogen flame ionization detector as detector, Nn- dimethyl acetamide as solvent, and temperature programmed mode for the determination of methanol in parpiperidone raw drug. Residues of ethyl acetate, dichloromethane and triethylamine. Results all of the four volatile organic solvents reached the baseline separation. The internal linearity of the four volatile organic solvents was good (r 鈮，

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