【摘要】：尿路上皮癌胚抗原1(UCA1)是在膀胱癌中發(fā)現(xiàn)的一種長鏈非編碼RNA(lncRNA),在膀胱癌、乳腺癌、黑色素瘤等多種腫瘤中存在差異表達。UCA1可對多種信號通路進行調(diào)控,并且作為競爭性內(nèi)源RNA(ceRNA)參與轉(zhuǎn)錄后調(diào)控。近期研究發(fā)現(xiàn)UCA1的異常表達與腫瘤化療耐藥密切相關(guān),有望成為腫瘤化療耐藥的潛在靶標,為逆轉(zhuǎn)腫瘤耐藥提供新思路。本文就UCA1參與腫瘤化療耐藥調(diào)節(jié)的具體分子機制作一綜述。
[Abstract]:Urothelial carcinoembryonic antigen 1 (UCA1) is a long chain noncoding RNA (lncRNA), found in bladder cancer. UCA1 can regulate many signal pathways in bladder cancer, breast cancer, melanoma and other tumors. And as a competitive endogenous RNA (ceRNA) involved in post-transcriptional regulation. Recent studies have found that the abnormal expression of UCA1 is closely related to the chemotherapeutic resistance of tumor, which is expected to be a potential target of chemotherapeutic resistance, and provides a new way to reverse the drug resistance of tumor. This article reviews the molecular mechanism of UCA1 involved in the regulation of chemotherapeutic resistance.
【作者單位】： 南華大學藥物藥理研究所湖南省分子靶標新藥研究協(xié)同創(chuàng)新中心;
【基金】：國家自然科學基金資助項目(81372579)
【分類號】：R96
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本文編號：2340971