發(fā)布時(shí)間：2018-10-20 12:22

【摘要】：目的制備利福平脂質(zhì)體溫敏型原位凝膠,并對(duì)其體外性質(zhì)進(jìn)行研究。方法采用薄膜分散法制備利福平脂質(zhì)體,并對(duì)利福平脂質(zhì)體進(jìn)行表征研究;以泊洛沙姆188、泊洛沙姆407為凝膠基質(zhì),制備利福平脂質(zhì)體溫敏型原位凝膠;以無膜溶出模型研究溫敏型原位凝膠體外累積溶蝕率;采用透析袋法分析藥物體外釋放情況。結(jié)果制備的利福平脂質(zhì)體平均粒徑、聚分散指數(shù)、Zeta電位、包封率和載藥量分別為(149.0±5.67)nm、0.275±0.056、?(29.8±1.59)m V、(79.6±2.67)%,(18.6±0.25)%;利福平脂質(zhì)體溫敏型原位凝膠的膠凝溫度為(34.3±0.6)℃。體外溶蝕曲線和體外釋藥曲線均符合零級(jí)動(dòng)力學(xué)特征。結(jié)論利福平脂質(zhì)體溫敏型原位凝膠的制備工藝簡(jiǎn)單易行,體外釋放顯示其有很好的緩釋作用。
[Abstract]:Objective to prepare rifampicin lipids in situ gel and study its properties in vitro. Methods Rifampicin liposomes were prepared by thin-film dispersion method, and the liposomes were characterized by using Poloxamer 188and Poloxamer 407 as gel matrix, and rifampicin liposome thermo-sensitive in situ gel was prepared with Poloxamer 188and Poloxamer 407 as gel matrix. The in vitro cumulative dissolution rate of thermosensitive in situ gel was studied by using membrane free dissolution model, and the drug release in vitro was analyzed by dialysate bag method. Results the average particle size, polydispersity index, Zeta potential, encapsulation efficiency and drug loading capacity of rifampicin liposome were (149.0 鹵5.67) nm,0.275 鹵0.056? (29.8 鹵1.59) m V, (79.6 鹵2.67)%, (18.6 鹵0.25)%, respectively, and the gelation temperature of rifampicin liposome in situ gel was (34.3 鹵0.6) 鈩，

本文編號(hào)：2283167