【摘要】：自微乳化遞藥系統(tǒng)(SMEDDS)口服后在胃腸道運(yùn)動(dòng)的促進(jìn)下,能快速自發(fā)乳化形成粒徑均一的微乳。它可增加難溶性藥物的溶解度和生物利用度。對于SMEDDS的質(zhì)量評價(jià)也日益受到重視。本文較全面地綜述了能反映SMEDDS結(jié)構(gòu)、穩(wěn)定性和體外釋放行為的質(zhì)量評價(jià)項(xiàng)目及方法。此外,簡要介紹了SMEDDS與固體分散、吸附、擠出滾圓等技術(shù)相結(jié)合得到的自微乳固體制劑給藥系統(tǒng)(S-SMEDDS)及質(zhì)量評價(jià)。
[Abstract]:After oral administration of (SMEDDS), a self-emulsifying drug delivery system, promoted by gastrointestinal motility, the microemulsion with uniform particle size was formed by rapid spontaneous emulsification. It can increase the solubility and bioavailability of insoluble drugs. More and more attention has been paid to the quality evaluation of SMEDDS. In this paper, the quality evaluation items and methods which can reflect the structure, stability and release behavior of SMEDDS in vitro are reviewed. In addition, the drug delivery system (S-SMEDDS) and quality evaluation of self-microemulsion solid preparation (S-SMEDDS) obtained by combining SMEDDS with solid dispersion, adsorption and extrusion roundness were briefly introduced.
【作者單位】： 中國醫(yī)藥工業(yè)研究總院藥物制劑國家工程研究中心;
【分類號】：R943

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