本文選題：甘草次酸脂化乳 + 質(zhì)量評(píng)價(jià)　； 參考：《中國(guó)藥房》2017年06期

【摘要】：目的:為甘草次酸脂化乳的質(zhì)量評(píng)價(jià)提供參考指標(biāo)。方法:采用冷凍透射電子顯微鏡檢測(cè)甘草次酸脂化乳粒子形態(tài),激光納米粒度儀測(cè)定其粒徑、多分散系數(shù)(PDI)及電位情況;采用超高效液相色譜法測(cè)定其中有效成分甘草次酸的載藥量;在30℃下放置10 d考察該制劑的穩(wěn)定性。結(jié)果:制備的甘草次酸脂化乳輪廓清晰、結(jié)構(gòu)完整、呈類(lèi)圓形、排列緊密;平均粒徑為(245.2±4.29)nm,PDI為(0.054±0.01),平均電位為(-6.25±0.54)m V;甘草次酸的載藥量平均值為(1.25±0.09)mg/m L;質(zhì)量濃度為0.82 mg/m L的樣品在10 d內(nèi)穩(wěn)定性良好。結(jié)論:粒徑、電位、載藥量、穩(wěn)定性可作為甘草次酸脂化乳的評(píng)價(jià)指標(biāo)。
[Abstract]:Objective: to provide a reference index for the quality evaluation of liquorice fatty milk. Methods: the morphology of lipidized glycyrrhetinic acid emulsion was detected by freezing transmission electron microscope. The particle size, polydispersity coefficient (PDI) and potential were measured by laser nanocrystalline analyzer. The drug loading capacity of glycyrrhetinic acid was determined by ultra-high performance liquid chromatography, and the stability of the preparation was investigated at 30 鈩，

本文編號(hào)：2098534