本文選題：甲基丙烯酸-丙烯酸乙酯共聚物 + 有關(guān)物質(zhì)�。� 參考：《中國藥房》2015年24期

【摘要】：目的:建立測定甲基丙烯酸-丙烯酸乙酯共聚物中有關(guān)物質(zhì)含量的方法。方法:采用高效液相色譜法。色譜柱為Agilent C18,流動相為甲醇-磷酸鹽緩沖液(30∶70,V/V),流速為1.0 ml/min,檢測波長為202 nm,柱溫為20℃,進(jìn)樣量為20μl。結(jié)果:甲基丙烯酸和丙烯酸乙酯質(zhì)量分?jǐn)?shù)在0.001%~0.015%范圍內(nèi)均與其峰面積呈良好的線性關(guān)系(r=0.999 4、0.999 1);精密度、穩(wěn)定性和重復(fù)性試驗(yàn)的RSD均2%;甲基丙烯酸平均加樣回收率為86.59%,RSD為2.3%(n=9),丙烯酸乙酯平均加樣回收率為91.24%,RSD為3.5%(n=9)。結(jié)論:該方法簡單、準(zhǔn)確、重復(fù)性好,可用于甲基丙烯酸-丙烯酸乙酯共聚物中有關(guān)物質(zhì)的含量測定。
[Abstract]:Objective: to establish a method for the determination of related substances in methacrylic acid-ethyl acrylate copolymers. Methods: high performance liquid chromatography was used. The chromatographic column was Agilent C18, the mobile phase was methanol-phosphate buffer (30: 70 V / V), the flow rate was 1.0 ml / min, the detection wavelength was 202nm, the column temperature was 20 鈩，

本文編號：2064021