本文選題：高效液相色譜法 + 注射用頭孢匹林鈉�。� 參考：《中國(guó)抗生素雜志》2015年09期

【摘要】：目的考察注射用頭孢匹林鈉在使用過(guò)程中分別與0.9%氯化鈉注射液、5%葡萄糖注射液、10%葡萄糖注射液的配伍穩(wěn)定性。方法采用高效液相色譜法,使用C18色譜柱(SB-C18,4.6mm×250mm,5μm);流動(dòng)相為0.05mol/L磷酸二氫鉀溶液(用10%磷酸溶液調(diào)節(jié)p H值至2.6)-乙腈(88:12);檢測(cè)波長(zhǎng)為254nm;柱溫為35℃;進(jìn)樣量為20μL。結(jié)果注射用頭孢匹林鈉分別與0.9%氯化鈉注射液、5%葡萄糖注射液、10%葡萄糖注射液配伍使用,在6h內(nèi)溶液的外觀、p H值、有關(guān)物質(zhì)及含量均無(wú)明顯差異;但放置24小時(shí)后,有關(guān)物質(zhì)或含量均已不合格。結(jié)論建議注射用頭孢匹林鈉與0.9%氯化鈉注射液、5%葡萄糖注射液、10%葡萄糖注射液配伍應(yīng)在6h內(nèi)使用完畢。
[Abstract]:Objective to investigate the compatibility stability of cefpiline sodium for injection with 0.9% sodium chloride injection, 5% glucose injection and 10% glucose injection. Methods High performance liquid chromatography (HPLC) was used with C _ (18) column SB-C186mm 脳 250mm ~ 5 渭 m ~ (-1), the mobile phase was 0.05mol/L potassium dihydrogen phosphate solution (pH value was adjusted to 2.6-acetonitrile 88: 12) with 10% phosphoric acid solution, the detection wavelength was 254 nm, the column temperature was 35 鈩，

本文編號(hào)：1885210