本文選題：漢防己甲素 + 聚乳酸-羥基乙酸共聚物��； 參考：《中國藥學(xué)雜志》2015年21期

【摘要】：目的制備載漢防己甲素的磁性聚乳酸-羥基乙酸共聚物(PLGA)納米粒,通過磁感應(yīng)誘導(dǎo)加熱納米粒,研究加熱前后載藥磁性納米粒粒徑,形態(tài)學(xué)及藥物釋放的變化。方法采用乳化分散溶劑揮發(fā)法制備載漢防己甲素聚乳酸-羥基乙酸共聚物磁性納米粒;利用激光粒徑儀(DLS)、掃描電鏡(SEM)、透射電鏡(TEM)、振動樣品磁強(qiáng)計(VSM)對納米粒的理化性質(zhì)及磁性能進(jìn)行考察;采用RP-HPLC及ICP-MS測定藥物及Fe3O4載藥量、包封率。EASYHEAT磁感應(yīng)加熱系統(tǒng)對載藥納米粒進(jìn)行加熱,考察加熱前后納米粒粒徑,形態(tài)及藥物釋放量的變化。結(jié)果載漢防己甲素聚乳酸-羥基乙酸共聚物磁性納米粒呈大小均一,表面光滑圓球形,磁性顆粒均勻分散在聚乳酸-羥基乙酸共聚物納米粒內(nèi)部;振動樣品磁強(qiáng)計結(jié)果顯示,載漢防己甲素磁性聚乳酸-羥基乙酸共聚物納米粒具有良好的超順磁性;漢防己甲素及Fe3O4均具有良好的包封率和載藥量。運(yùn)用磁感應(yīng)加熱至45℃后,磁性納米粒粒徑變大,形態(tài)發(fā)生聚集破裂,聚乳酸-羥基乙酸共聚物納米粒內(nèi)Fe3O4磁性顆粒發(fā)生重排,藥物釋放量明顯增加。結(jié)論具超順磁性載漢防己甲素聚乳酸-羥基乙酸共聚物納米粒,在磁感應(yīng)加熱作用下,能有效控制藥物的釋放。
[Abstract]:Objective to prepare magnetic polylactic acid-glycolic acid (PLGA) nanoparticles loaded with Tetrandrine (Tetrandrine), and to study the changes of particle size, morphology and drug release before and after heating. Methods the magnetic nanoparticles of Tetrandrine loaded polylactic acid-glycolic acid copolymers were prepared by emulsifying and dispersing solvent volatilization method. The physicochemical properties and magnetic properties of the nanoparticles were investigated by laser particle size analyzer, scanning electron microscope (SEM), transmission electron microscope (TEM) and vibratory sample magnetometer (VSM), and the amount of drugs and Fe3O4 loaded in the nanoparticles were determined by RP-HPLC and ICP-MS. The encapsulation efficiency. EASYHEAT magnetic induction heating system was used to heat the drug loaded nanoparticles. The changes of particle size, morphology and drug release before and after heating were investigated. Results the magnetic nanoparticles of Tetrandrine (Tetrandrine) polylactic acid-glycolic acid copolymers were uniform in size, and the surface was smooth and spherical, the magnetic particles were evenly dispersed in the interior of polylactic acid-glycolic acid copolymer nanoparticles, and the results of vibrating sample magnetometer showed that, Tetrandrine loaded magnetic poly (lactic acid-glycolic acid) copolymer nanoparticles have good superparamagnetic properties, Tetrandrine and Fe3O4 have good encapsulation efficiency and drug loading. When heated to 45 鈩，

本文編號：1850362