本文選題：高血壓 + 腦白質病�。� 參考：《中國神經精神疾病雜志》2015年02期

【摘要】：目的探討瑞舒伐他汀鈣對慢性高血壓大鼠的腦白質病變及其空間認知功能障礙的影響。方法雄性Sprague-Daw Iey大鼠49只,隨機分為假手術組、高血壓組和瑞舒伐他汀鈣治療組(10 mg/kg)。高血壓組和瑞舒伐他汀鈣治療組采用雙腎雙夾法制作易卒中型腎血管性高血壓大鼠(stroke-prone renovascular hypertensive rat,RHRSP)模型,定期監(jiān)測血壓。水迷宮實驗檢測空間記憶功能;Luxol fast blue染色觀察腦白質疏松程度;免疫熒光法觀察額葉皮層β-淀粉樣蛋白(β-amyloid,Aβ)在大腦皮層的沉積分布;原位末端轉移酶標記染色法(Td T-mediated d UTP-biotin nick end labeling,TUNEL)觀察額葉皮層細胞凋亡水平。結果 RHRSP大鼠造模后血壓逐漸升高,明顯高于假手術組(P0.01);瑞舒伐他汀鈣較高血壓組逃避潛伏期時間明顯縮短(P0.01),3組大鼠跨越平臺次數分別為(4.55±1.23)、(1.00±0.80)、(3.79±0.95),差異有統(tǒng)計學意義(P0.01)。與高血壓組相比,瑞舒伐他汀鈣可改善腦白質疏松程度(P0.01),減少額葉皮層區(qū)Aβ沉積(17.47±3.59 vs.4.42±1.57,P0.01)及細胞凋亡(37.84±4.73 vs.14.42±2.43,P0.01)。結論瑞舒伐他汀鈣可改善慢性高血壓大鼠的腦白質病變,減少額葉皮層區(qū)Aβ沉積以及細胞凋亡從而保護大鼠的空間記憶功能。
[Abstract]:Objective to investigate the effects of rosuvastatin calcium on white matter lesions and spatial cognitive impairment in chronic hypertensive rats. Methods Forty-nine male Sprague-Daw Iey rats were randomly divided into three groups: sham operation group, hypertension group and rosuvastatin calcium treatment group. Hypertension group and rosuvastatin calcium treatment group were used to make stroke-prone renovascular hypertensive RHRSPs model by double kidney and double clip method, and blood pressure was monitored regularly. Water maze test was used to detect the degree of leukoaraiosis by Luxol fast blue staining and the distribution of 尾 -amyloid A 尾 in the frontal cortex by immunofluorescence. Tunel was used to observe the apoptosis level of frontal cortex cells by in situ terminal transferase labeling staining (TD T-mediated d UTP-biotin nick end Tunel staining). Results the blood pressure of RHRSP rats increased gradually, which was significantly higher than that of sham operation group (P 0.01), and the escape latency time of rosuvastatin calcium group was significantly shorter than that of hypertension group (P 0.01). The times of crossing the platform of rats in the three groups were 4.55 鹵1.23, 1.00 鹵0.80 and 3.79 鹵0.95respectively, and the difference was statistically significant (P 0.01). Compared with hypertension group, rosuvastatin calcium could improve the degree of leukoaraiosis and reduce A 尾 deposition in frontal cortex area (17.47 鹵3.59 vs.4.42 鹵1.57 vs.4.42, P 0.01) and apoptosis (37.84 鹵4.73 vs.14.42 鹵2.43 vs.14.42 鹵0.01g / L). Conclusion Risuvastatin calcium can improve the white matter lesion of chronic hypertensive rats, reduce A 尾 deposition in the frontal cortex and protect the spatial memory function of the rats.
【作者單位】： 中山大學附屬第一醫(yī)院神經科 教育部國家重點學科 衛(wèi)生部國家臨床重點�？� 廣東省重大神經疾病診治研究重點實驗室;香港中文大學威爾斯親王醫(yī)院內科與藥物治療系;
【基金】：國家自然科學青年基金(編號:81000514) 廣東省自然科學基金項目(編號:s2013010015840)
【分類號】：R965

【相似文獻】

相關期刊論文 前10條

1 趙麗娟;;瑞舒伐他汀的臨床應用[J];天津藥學;2012年02期

2 盛瑾;劉文嫻;李鵬;;瑞舒伐他汀對晚期內皮祖細胞增生、遷移及凋亡的影響[J];首都醫(yī)科大學學報;2012年06期

3 胡錦芳;溫金華;盛向遠;;瑞舒伐他汀口崩片的人體生物等效性研究與藥代動力學個體差異分析[J];南昌大學學報(醫(yī)學版);2012年12期

4 李紅旗;章琦;陳莉;嚴光;胡立群;;吡格列酮聯合瑞舒伐他汀有效抑制動脈粥樣硬化的作用[J];中華保健醫(yī)學雜志;2013年06期

5 呂曉東,貢聯兵;瑞舒伐他汀[J];中國新藥雜志;2002年08期

6 郭淑麗;陳作元;李姍;李霞;;瑞舒伐他汀對糖尿病大鼠早期動脈粥樣硬化形成的影響(英文)[J];現代生物醫(yī)學進展;2011年02期

7 徐鑫;趙鍇;;8羥基脫氧鳥苷在2型糖尿病大鼠腎臟的表達及瑞舒伐他汀鈣的影響[J];中國實用醫(yī)藥;2011年35期

8 秦t，

本文編號：1837705