本文選題：載藥熒光納米粒子 + 自組裝�。� 參考：《高等學(xué)校化學(xué)學(xué)報》2017年05期

【摘要】：利用兩親性聚乙二醇-聚乳酸共聚物(PEG-PDLLA)包覆熒光染料(DPBA)和紫杉醇(PTX),通過自組裝方法制得載藥熒光納米粒子DPBA/PTX@PEG-PDLLA.納米粒子尺寸均一,具有良好的生物相容性.對納米粒子的發(fā)光性質(zhì)、載藥量和體外藥物釋放等進(jìn)行了表征,并考察了納米粒子對乳腺癌細(xì)胞MCF-7的抑制效果,觀察了MCF-7細(xì)胞對納米粒子的攝取情況.結(jié)果表明,DPBA/PTX@PEG-PDLLA納米粒子具有較強(qiáng)的紅光發(fā)射,不僅可以用于MCF-7腫瘤細(xì)胞質(zhì)熒光成像,而且對腫瘤細(xì)胞的增殖具有一定的抑制能力.
[Abstract]:The fluorescent dye DPBA and paclitaxel were coated with amphiphilic poly (ethylene glycol) polylactic acid copolymer (PEG-PDLLA). The fluorescent nanoparticles DPBA / PTXPEG-PDLLAA were prepared by self-assembly method. The nanoparticles are homogeneous in size and have good biocompatibility. The luminescence properties, drug loading and drug release in vitro of nanoparticles were characterized. The inhibitory effect of nanoparticles on MCF-7 of breast cancer cells was investigated, and the uptake of nanoparticles in MCF-7 cells was observed. The results showed that DPBA / PTX @ PEG-PDLLA nanoparticles had strong red light emission, which could not only be used for fluorescence imaging of MCF-7 tumor cytoplasm, but also could inhibit the proliferation of tumor cells.
【作者單位】： 吉林大學(xué)第一醫(yī)院;東北師范大學(xué)計算機(jī)科學(xué)與信息技術(shù)學(xué)院;吉林大學(xué)超分子結(jié)構(gòu)與材料國家重點實驗室;
【基金】：吉林省科技廳自然科學(xué)基金項目(批準(zhǔn)號:20150101205JC) 吉林大學(xué)白求恩醫(yī)學(xué)科研支持計劃項目(批準(zhǔn)號:2013205023) 吉林大學(xué)第一醫(yī)院院青年基金(批準(zhǔn)號:JDYY72016040)資助~~
【分類號】：R943;R96;TB383.1
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本文編號：1813388