本文關(guān)鍵詞： 導(dǎo)管相關(guān)血栓 動物模型 低分子肝素 地塞米松　出處：《華中科技大學(xué)學(xué)報(醫(yī)學(xué)版)》2015年04期 　論文類型：期刊論文

【摘要】：目的建立穩(wěn)定的家兔頸靜脈導(dǎo)管相關(guān)血栓模型,并探討低分子肝素與地塞米松對其形成的影響。方法將60只日本大耳白兔分為對照組、低分子肝素組、地塞米松組和合用組。將中心靜脈導(dǎo)管(CVC)插入右側(cè)頸靜脈制造導(dǎo)管相關(guān)血栓動物模型。術(shù)后分別給予低分子肝素鈉/地塞米松。術(shù)后第7天觀察頸靜脈導(dǎo)管相關(guān)血栓形成情況及血漿內(nèi)D-D二聚體水平。結(jié)果成功建立簡便有效的日本大耳白兔導(dǎo)管相關(guān)血栓模型。低分子肝素組及合用組實驗兔導(dǎo)管相關(guān)血栓形成較對照組顯著降低,D-D二聚體水平明顯下降(P0.01)。結(jié)論應(yīng)用低分子肝素能有效預(yù)防導(dǎo)管相關(guān)血栓。糖皮質(zhì)激素抗炎治療可能對預(yù)防導(dǎo)管相關(guān)血栓形成有一定作用。
[Abstract]:Objective to establish a stable rabbit model of jugular catheter-related thrombus and to investigate the effects of low-molecular-weight heparin and dexamethasone on its formation. Methods 60 Japanese white rabbits were divided into control group and low-molecular-weight heparin group. In dexamethasone group and combined group, the central venous catheter CVC was inserted into the right jugular vein to make the animal model of catheter-associated thrombus. After operation, low-molecular-weight heparin sodium / dexamethasone was given respectively. The jugular catheter correlation was observed on the 7th day after operation. Results A simple and effective catheter-associated thrombus model was successfully established in Japanese large ear white rabbits. The experimental rabbits in low molecular weight heparin group and combination group were significantly higher than those in the control group. Conclusion the application of low molecular weight heparin can effectively prevent catheter-related thrombosis. Anti-inflammatory therapy with glucocorticoid may play a role in preventing catheter-related thrombosis.
【作者單位】： 華中科技大學(xué)同濟醫(yī)學(xué)院附屬同濟醫(yī)院肝臟外科中心-血管外科;華中科技大學(xué)同濟醫(yī)學(xué)院附屬同濟醫(yī)院PICC組;
【基金】：湖北省自然科學(xué)基金資助項目(No.2012FFB02521) 華中科技大學(xué)自主創(chuàng)新研究項目(No.01-18-540066)
【分類號】：R965

【共引文獻】

相關(guān)期刊論文 前5條

1 李屹壁;張亞芳;;低分子肝素預(yù)防老年骨科患者中心靜脈導(dǎo)管相關(guān)血栓形成的臨床觀察[J];華夏醫(yī)學(xué);2013年03期

2 張U，

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