本文關(guān)鍵詞： 普瑞巴林 扁桃酸 拆分過(guò)程 制備　出處：《鄭州大學(xué)學(xué)報(bào)(工學(xué)版)》2015年04期 　論文類型：期刊論文

【摘要】：對(duì)普瑞巴林化學(xué)拆分過(guò)程進(jìn)行研究.以S-(+)-扁桃酸為拆分劑對(duì)普瑞巴林消旋體進(jìn)行化學(xué)拆分,采用HPLC法測(cè)定拆分過(guò)程中各組分含量,考察不同拆分條件下各組分含量變化的規(guī)律,得出普瑞巴林較佳拆分條件,并進(jìn)行進(jìn)一步的驗(yàn)證試驗(yàn).基于該研究所獲得的較佳拆分條件重復(fù)性良好,所獲得的巴林含量可達(dá)99.5%以上,完全符合藥典要求,規(guī)�？蛇_(dá)到每批次合格品不少于100 g.該研究為普瑞巴林工業(yè)化制備提供了有價(jià)值的理論研究依據(jù).
[Abstract]:Study on chemical separation process by S-. Pregabalin (+) - mandelic acid as resolution agent of pregabalin racemic chemical resolution, HPLC method was used to determine the content of each component in the separation process, the effects of different separation conditions component content changes, obtained better resolution of pregabalin conditions, and verified further testing. Based on the study of better separation conditions obtained with good reproducibility, can be more than 99.5% of Bahrain was obtained, fully meet the requirements of Chinese Pharmacopoeia, the size of each batch of qualified products can reach no less than 100 g. for the study of Bahrain Puri industrialization preparation provides valuable theoretical basis for research.

【作者單位】： 鄭州大學(xué)化工與能源學(xué)院;河南輔仁醫(yī)藥科技開(kāi)發(fā)有限公司;
【基金】：河南省科技廳產(chǎn)學(xué)研合作項(xiàng)目(132107000016) 河南省教育廳科學(xué)技術(shù)研究重點(diǎn)資助項(xiàng)目(14A530007)
【分類號(hào)】：R914

【參考文獻(xiàn)】

相關(guān)期刊論文 前5條

1 楊健;黃燕;;普瑞巴林的合成[J];高�；瘜W(xué)工程學(xué)報(bào);2009年05期

2 李t，

本文編號(hào)：1529646