本文關(guān)鍵詞： 亞砷酸鈉 一般毒性 砷含量　出處：《毒理學(xué)雜志》2017年05期 　論文類型：期刊論文

【摘要】：目的動(dòng)態(tài)觀察低劑量砷染毒小鼠后其一般情況的變化。方法 96只健康雄性KM小鼠隨機(jī)分組,設(shè)0、50、500和5 000μg/L 4個(gè)染毒組,再將每個(gè)劑量組分4、6和8周3個(gè)染毒時(shí)間點(diǎn),經(jīng)飲水染毒,測(cè)定飲水量、飼料消耗量及主要的臟器系數(shù),用原子熒光吸收光譜法測(cè)血、肝和腎的總砷含量。結(jié)果體重在低和中劑量染毒4周明顯增高,高劑量組8周則顯著降低。肝臟和腎臟系數(shù)均是隨染毒時(shí)間和染毒劑量的增加出現(xiàn)先增高后降低的現(xiàn)象。脾臟和心臟系數(shù)均隨染毒時(shí)間和染毒劑量的增加而增加(P0.05),肺臟系數(shù)在中劑量有明顯增高(P0.05)。血砷、肝砷、腎砷含量隨著染毒時(shí)間和染毒劑量的增加而逐漸增高,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論短時(shí)間低劑量砷可以誘導(dǎo)小鼠代償性反應(yīng),隨著染毒時(shí)間和劑量的增加,主要臟器出現(xiàn)損傷。
[Abstract]:Objective to observe the changes of general situation of mice exposed to low dose arsenic. Methods 96 healthy male km mice were randomly divided into 4 groups: 0 50 渭 g / L and 5 000 渭 g / L. Then 3 time points of each dose component were given at 6 and 8 weeks. Drinking water quantity, feed consumption and main organ coefficient were measured. The blood was measured by atomic fluorescence absorption spectrometry (AFS). The contents of total arsenic in liver and kidney. Results the body weight was significantly increased at the low and middle dose for 4 weeks. The liver and kidney coefficients increased first and then decreased with the increase of exposure time and dose, and the coefficients of spleen and heart increased with the increase of exposure time and dose. (. P0.05). The lung coefficient was significantly increased in middle dose (P 0.05). The contents of arsenic in blood, liver and kidney gradually increased with the increase of exposure time and dose. Conclusion Low-dose arsenic can induce compensatory response in mice for a short time. With the increase of exposure time and dose, the main organs are damaged.
【作者單位】： 贛南醫(yī)學(xué)院預(yù)防醫(yī)學(xué)系;山西醫(yī)科大學(xué)衛(wèi)生毒理學(xué)教研室;
【基金】：江西省自然科學(xué)基金(20132BAB205071,20114BAB205041,2014BAB215013) 江西省教育廳科學(xué)技術(shù)研究(GJJ13689,GJJ14699) 江西省衛(wèi)生廳科技計(jì)劃(20113133)
【分類號(hào)】：R99
【正文快照】： 砷是自然界中廣泛存在的一種類金屬元素,可通過(guò)飲水、燃煤、農(nóng)藥及藥品或飼料添加劑等多種途徑進(jìn)入人類的生活環(huán)境中。長(zhǎng)期高濃度接觸砷可以引起慢性砷中毒,以往的研究多集中于研究高濃度砷對(duì)機(jī)體的影響,但是越來(lái)越來(lái)的研究發(fā)現(xiàn),低濃度砷長(zhǎng)時(shí)間接觸對(duì)機(jī)體造成一定的影響,低中，

本文編號(hào)：1447322