本文關(guān)鍵詞：一種水凝膠敷料的制備及其對(duì)SD大鼠深Ⅱ度燒傷創(chuàng)面的愈合作用　出處：《中國(guó)藥學(xué)雜志》2016年20期 　論文類型：期刊論文

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【摘要】：目的制備一種水凝膠敷料并考察其對(duì)SD大鼠深Ⅱ度燒傷創(chuàng)面的愈合作用。方法制備水凝膠敷料,并篩選其滅菌方法。采用新西蘭兔考察其皮膚刺激性。采用熱固體燙傷法制備SD大鼠深Ⅱ度燒傷模型,采用清得佳及長(zhǎng)海醫(yī)院院內(nèi)制劑脫痂軟膏為陽(yáng)性對(duì)照,考察水凝膠敷料對(duì)其創(chuàng)面愈合作用。結(jié)果制備的水凝膠敷料澄清、透明,黏度與陽(yáng)性對(duì)照藥物清得佳一致。輻射滅菌后,水凝膠敷料黏度急劇下降,高壓蒸汽滅菌前后,黏度無(wú)顯著性變化。水凝膠敷料對(duì)兔皮膚無(wú)顯著刺激性。與清得佳及脫痂軟膏相比,實(shí)驗(yàn)組愈合時(shí)間無(wú)顯著性差異;與模型對(duì)照組相比,愈合時(shí)間有顯著性差異(P0.01)。結(jié)論以羥乙基纖維素為基質(zhì)制備的水凝膠敷料,黏度適宜,澄清透明,易于觀察創(chuàng)面愈合情況,無(wú)顯著皮膚刺激性,可顯著促進(jìn)SD大鼠深Ⅱ度燒傷創(chuàng)面的愈合,具有廣闊的應(yīng)用前景。
[Abstract]:Objective to prepare a hydrogel dressing and investigate its healing effect on deep second degree burn wounds in SD rats. The skin irritation was investigated by New Zealand rabbit. The SD rat model of deep second degree burn was made by hot solid scald method. Qingdejia and Changhai hospital were used as positive control. The effect of hydrogel dressing on wound healing was investigated. Results the prepared hydrogel dressing was clear and transparent, and the viscosity of hydrogel dressing was consistent with that of the positive control drug. After radiation sterilization, the viscosity of hydrogel dressing decreased sharply. There was no significant change in viscosity before and after high pressure steam sterilization. Hydrogel dressing had no significant irritation on rabbit skin. There was no significant difference in healing time between the experimental group and Qingdejia and descab ointment. Compared with the model control group, the healing time was significantly different (P 0.01). Conclusion the hydrogel dressing prepared with hydroxyethyl cellulose is suitable for viscosity, clear and transparent, and easy to observe wound healing. No significant skin irritation can significantly promote the healing of deep second degree burn wounds in SD rats, which has a broad application prospect.
【作者單位】： 第二軍醫(yī)大學(xué)長(zhǎng)海醫(yī)院藥學(xué)部;戰(zhàn)略支援部隊(duì)航天系統(tǒng)部航天城門(mén)診部;
【基金】：長(zhǎng)海醫(yī)院“1255”特色提升項(xiàng)目(CH125520400);長(zhǎng)海醫(yī)院青年啟動(dòng)基金資助項(xiàng)目(CH201510) 上海市科委中醫(yī)重點(diǎn)項(xiàng)目(13401902300) 上海市藥學(xué)會(huì)醫(yī)院藥學(xué)基金資助項(xiàng)目(2014-YY-02-11)
【分類號(hào)】：R943;R965
【正文快照】： 天城門(mén)診部,北京10094)深Ⅱ度燒傷創(chuàng)面是指熱力的損傷累及到真皮的深層[1]。目前的治療方法主要有2種,一是早期行創(chuàng)面削痂植皮,祛除壞死病灶,免除創(chuàng)面感染因素,縮短愈合時(shí)間,減少瘢痕增生,但是手術(shù)削痂清創(chuàng)會(huì)導(dǎo)致部分健康組織和間生態(tài)組織損失,造成不必要的損傷。另一方法是自，

本文編號(hào)：1361222