大鼠原代肝星狀細胞活化過程中CCN家族表達研究
發(fā)布時間：2018-11-07 07:25
【摘要】：肝纖維化是肝臟損傷后的病理性修復反應,其特征是肝臟中肝星狀細胞(HSC)激活、擴增和細胞外基質蛋白過度沉積。CCN蛋白因子是具信號傳遞功能的細胞基質蛋白,參與組織修復反應并涉及肝纖維化發(fā)生發(fā)展。本文制備了高純度的大鼠原代HSC并通過體外培養(yǎng)進行激活,同步定量分析了6個CCN因子在激活過程中的表達,以期對CCN因子在HSC激活過程中的作用進行更全面的評價。
[Abstract]:Hepatic fibrosis is a pathological repair response after liver injury, which is characterized by activation of (HSC), amplification and excessive deposition of extracellular matrix proteins in hepatic stellate cells. CCN protein factor is a cellular matrix protein with signal transduction function. Participate in tissue repair response and involve the development of liver fibrosis. High purity rat HSC was prepared and activated by culture in vitro. The expression of 6 CCN factors in the process of activation was analyzed quantitatively in order to evaluate the role of CCN factor in the process of HSC activation.
【作者單位】： 西南交通大學生命科學與工程學院;西南交通大學材料科學與工程學院;
【基金】：國家自然科學基金(81371675)
【分類號】：R575.2
，
本文編號：2315640
[Abstract]:Hepatic fibrosis is a pathological repair response after liver injury, which is characterized by activation of (HSC), amplification and excessive deposition of extracellular matrix proteins in hepatic stellate cells. CCN protein factor is a cellular matrix protein with signal transduction function. Participate in tissue repair response and involve the development of liver fibrosis. High purity rat HSC was prepared and activated by culture in vitro. The expression of 6 CCN factors in the process of activation was analyzed quantitatively in order to evaluate the role of CCN factor in the process of HSC activation.
【作者單位】： 西南交通大學生命科學與工程學院;西南交通大學材料科學與工程學院;
【基金】：國家自然科學基金(81371675)
【分類號】：R575.2
，
本文編號：2315640
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