【摘要】：目的系統(tǒng)性評價前列地爾聯(lián)合生長抑素治療重癥急性胰腺炎的療效和安全性。方法檢索PubMed、Cochrane library、Web of Science、萬方數(shù)據(jù)庫、中國知網(wǎng)數(shù)據(jù)庫、中國生物醫(yī)學(xué)數(shù)據(jù)庫,檢索時限均設(shè)定為各數(shù)據(jù)庫建庫至2015年11月,收集所有前列地爾聯(lián)合生長抑素治療重癥急性胰腺炎的隨機對照試驗,應(yīng)用RevMan 5.3軟件對數(shù)據(jù)進行Meta分析。結(jié)果納入11篇文獻,共927例患者。Meta分析結(jié)果顯示:與對照組相比,前列地爾聯(lián)合生長抑素治療組可以顯著提高總有效率[OR=5.45,95%CI(3.48,8.52),P0.01],改善臨床癥狀緩解時間[均數(shù)差(MD)=-15.20,95%CI(-18.17,-12.23),P0.01],血淀粉酶[MD=-26.59,95%CI(-29.85,-23.34),P0.01],血C反應(yīng)蛋白[MD=-23.95,95%CI(-27.68,-20.22),P0.01],血白細胞介素-6[MD=-12.40,95%CI(-15.69,-9.11),P0.01],組間比較差異均有統(tǒng)計學(xué)意義。此外,不良反應(yīng)發(fā)生率較低。結(jié)論在傳統(tǒng)治療基礎(chǔ)上加用前列地爾聯(lián)合生長抑素可以有效提高重癥急性胰腺炎的治療效果,且安全性高,值得臨床推廣。
[Abstract]:Objective to evaluate the efficacy and safety of alprostadil combined with somatostatin in the treatment of severe acute pancreatitis. Methods We searched PubMedus Cochrane libraryweb of Science, Wanfang Database, China knowledge Web Database and Chinese Biomedical Database. The searching time limit was set up until November 2015. All the randomized controlled trials of alprostadil combined with somatostatin in the treatment of severe acute pancreatitis were collected. The data were analyzed by Meta using RevMan 5.3 software. Results A total of 927 patients were included in 11 articles. The results of Meta-analysis showed that: compared with the control group, 鍓嶅垪鍦板皵鑱斿悎鐢熼暱鎶戠礌娌葷枟緇勫彲浠ユ樉钁楁彁楂樻，

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