發(fā)布時間：2018-04-18 00:27

  本文選題：干擾素αb + 干擾素αb��； 參考：《中國藥房》2016年23期

【摘要】：目的:比較干擾素α1b與α2b治療慢性丙型肝炎的經(jīng)濟性。方法:采用回顧性研究方法,選擇114例接受干擾素治療的慢性丙型肝炎患者,將其中采用干擾素α1b治療的60例作為A組,采用干擾素α2b治療的54例作為B組,比較兩組患者的丙型肝炎病毒(HCV)-RNA轉(zhuǎn)陰率、丙氨酸轉(zhuǎn)氨酶(ALT)復(fù)常率和不良反應(yīng)發(fā)生率,并進(jìn)行藥物經(jīng)濟學(xué)分析。結(jié)果:A組患者治療4、12、24、36、48周時的HCV-RNA轉(zhuǎn)陰率分別為55.00%、71.67%、63.33%、61.67%、65.00%,B組患者在上述各時間的HCV-RNA轉(zhuǎn)陰率分別為64.81%、66.67%、62.96%、55.56%、61.11%,組間比較差異均無統(tǒng)計學(xué)意義(P0.05);治療結(jié)束時,A組患者的ALT復(fù)常率為95.23%,B組為96.10%,組間比較差異無統(tǒng)計學(xué)意義(P0.05);兩組患者各種不良反應(yīng)發(fā)生率比較,差異均無統(tǒng)計學(xué)意義(P0.05),故采用最小成本法進(jìn)行藥物經(jīng)濟學(xué)分析。A組的治療成本為13 216.56元,B組為7 929.60元,B組的成本明顯低于A組;敏感度分析得到同樣的結(jié)果。結(jié)論:干擾素α2b治療慢性丙型肝炎較干擾素α1b更為經(jīng)濟。
[Abstract]:Objective: to compare the economic efficiency of interferon 偽 1b and 偽 2b in the treatment of chronic hepatitis C.Methods: a retrospective study was carried out in 114 patients with chronic hepatitis C treated with interferon, 60 of whom were treated with interferon 偽 1b as group A and 54 as group B treated with interferon 偽 2b.The rates of HCV seroconversion, alanine aminotransferase (alt) reversion and adverse reactions were compared between the two groups, and the pharmacoeconomic analysis was carried out.Results at 48 weeks after treatment, the HCV-RNA negative conversion rate of group A was 55.00 and 71.67, respectively. The rate of ALT conversion in group B was 64.81and 64.81and 66.6762.9655.565.51, respectively. There was no significant difference between the two groups (P 0.05); at the end of the treatment, the ALT recovery rate of patients in group A was 95.2323.96.10, there was no significant difference between the two groups (P 0.05); the incidence of various adverse reactions in the two groups was higher than that in the control group.There was no significant difference between the two groups, so the cost of treatment in group A was 13 216.56 yuan and that in group B was 7 929.60 yuan, which was significantly lower than that in group A, and the sensitivity analysis showed the same result.Conclusion: interferon 偽 2b is more economical than interferon 偽 1b in the treatment of chronic hepatitis C.
【作者單位】： 成都市公共衛(wèi)生臨床醫(yī)療中心;
【基金】：國家科技重大專項課題(No.2012ZX10005004-003)
【分類號】：R512.63

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