本文選題：阻塞性睡眠呼吸暫停低通氣綜合征 + 高血壓　； 參考：《新疆醫(yī)科大學》2017年碩士論文

【摘要】：目的:探討血清甲狀腺激素、甲狀腺轉(zhuǎn)錄因子-1(TTF-1)與阻塞性睡眠呼吸暫停低通氣綜合征(OSAHS)的相關(guān)性。方法:回顧性分析2015年1月-2015年12月在新疆維吾爾自治區(qū)人民醫(yī)院高血壓科就診的338例可疑OSAHS患者,并行多導睡眠監(jiān)測(PSG),根據(jù)呼吸暫停低通氣指數(shù)(AHI)分為非OSAHS組及輕度、中度和重度OSAHS組。分別從非OSAHS組和重度OSAHS組各隨機抽取40例患者,檢測兩組的血清TTF-1濃度,以及4組患者的甲狀腺功能;并分析其與OSAHS的相關(guān)性。結(jié)果:根據(jù)呼吸暫停低通氣指數(shù)(AHI)將入選的338例患者分為4分組:非OSAHS組134例、輕度OSAHS組69例、中度OSAHS組58例、重度OSAHS組77例。研究觀察的40例非OSAHS患者和40例重度OSAHS患者的血清TTF-1水平,發(fā)現(xiàn)兩組間的TTF-1水平未見明顯差異(P0.05)。4組患者甲狀腺激素的比較顯示,游離甲狀腺素(FT4)水平隨OSAHS嚴重程度加重而增加(P0.05)。相關(guān)性分析顯示FT4與性別、AHI和PRA存在明顯的相關(guān)性。多元線性回歸分析提示:AHI、體重指數(shù)(BMI)和腎素活性(PRA)可能是影響OSAHS患者FT4水平變化的危險因素(P0.05)結(jié)論:1.OSAHS患者TTF-1水平未見明顯的改變,TTF-1可能不能作為篩查OSAHS的生物標志物。2.OSAHS可引起甲狀腺激素水平的變化,AHI、BMI和PRA是影響OSAHS患者FT4水平的主要危險因素,提示OSAHS可能是甲狀腺疾病發(fā)生的危險因素。
[Abstract]:Aim: to investigate the relationship between serum thyroid hormone, thyroid transcription factor -1 and OSAHS1 in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: a retrospective analysis of 338 suspected OSAHS patients from January 2015 to December 2015 in the Department of Hypertension, Xinjiang Uygur Autonomous region people's Hospital, was performed. The patients were divided into non-OSAHS group and mild OSAHS group according to apnea hypopnea index (AHII). Moderate and severe OSAHS groups. The serum TTF-1 concentration and thyroid function were measured in 40 patients from non-OSAHS group and 40 patients with severe OSAHS group, and the correlation between TTF-1 and OSAHS was analyzed. Results: according to apnea hypopnea index (AHI), 338 patients were divided into 4 groups: nonOSAHS group (n = 134), mild OSAHS group (n = 69), moderate OSAHS group (n = 58) and severe OSAHS group (n = 77). The serum TTF-1 levels of 40 non-OSAHS patients and 40 severe OSAHS patients were observed. There was no significant difference in TTF-1 levels between the two groups. The results showed that the level of free thyroxine FT4 increased with the severity of OSAHS. Correlation analysis showed that FT4 was significantly correlated with AHI and PRA. Multiple linear regression analysis suggested that the weight index (BMI) and renin activity (PRA) might be the risk factors influencing the change of FT4 level in OSAHS patients (P 0.05) conclusion: 1. TTF-1 level in OSAHS patients does not change significantly. TTF-1 may not be a biological marker for OSAHS screening. OSAHS may cause changes in thyroid hormone levels. AHI BMI and PRA are the main risk factors affecting FT4 levels in OSAHS patients. The results suggest that OSAHS may be a risk factor for thyroid disease.
【學位授予單位】：新疆醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R766

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