變應(yīng)性氣道炎癥動(dòng)物模型研究進(jìn)展
發(fā)布時(shí)間:2018-03-17 18:16
本文選題:變態(tài)反應(yīng) 切入點(diǎn):氣道炎癥 出處:《醫(yī)學(xué)研究生學(xué)報(bào)》2017年09期 論文類型:期刊論文
【摘要】:變應(yīng)性氣道炎癥(AAI)是以氣道高反應(yīng)性、氣道炎癥反應(yīng)、黏液分泌增多、氣道重塑等為主要特征的病理生理過(guò)程。動(dòng)物模型的構(gòu)建是研究AAI相關(guān)病理生理機(jī)制的重要手段。隨著生物技術(shù)的不斷發(fā)展,AAI動(dòng)物模型的構(gòu)建發(fā)展加快。文章就AAI動(dòng)物模型的動(dòng)物選擇、變應(yīng)原選擇、動(dòng)物模型建立方法、動(dòng)物模型評(píng)價(jià)等進(jìn)行綜述。
[Abstract]:Allergic airway inflammation (AAI) is characterized by airway hyperresponsiveness, airway inflammation, and increased mucus secretion. Airway remodeling is the main pathophysiological process. The construction of animal model is an important means to study the pathophysiological mechanism of AAI. With the development of biotechnology, the construction of animal model of AAI has been accelerated. Animal selection for AAI animal models, The selection of allergens, the establishment of animal models and the evaluation of animal models were reviewed.
【作者單位】: 廣州軍區(qū)廣州總醫(yī)院耳鼻喉科;
【基金】:國(guó)家自然科學(xué)基金(81300817)
【分類號(hào)】:R-332;R562.25;R765.21
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