終板軟骨細胞退變相關信號通路的研究進展
發(fā)布時間：2018-07-15 21:12
【摘要】：正椎間盤退變性疾病是臨床常見病和多發(fā)病,目前研究認為,影響椎間盤退變的主要因素有炎癥反應、氧化應激和機械應力等~[1~3]。在這些因素的作用下,椎間盤軟骨終板發(fā)生病理性改變,出現終板鈣化,導致營養(yǎng)物質彌散障礙,是椎間盤退變的始動因素~[4],而終板軟骨細胞肥大、凋亡在終板鈣化中起主要作用~[5]。但目前對軟骨細胞退變的
[Abstract]:Degenerative disease of positive intervertebral disc is a common and frequent disease in clinic. At present, the main factors influencing degeneration of intervertebral disc are inflammatory reaction, oxidative stress and mechanical stress. Under the action of these factors, the endplate of the intervertebral disc has pathological changes and calcification of the endplate, which leads to nutrient dispersion disorder, which is the initiator of disc degeneration, and the endplate chondrocytes are hypertrophic. Apoptosis plays a major role in calcification of endplate. But at present, the degeneration of chondrocytes
【作者單位】： 廣州中醫(yī)藥大學研究生院;廣州中醫(yī)藥大學第一附屬醫(yī)院脊柱骨科;
【分類號】：R681.5
本文編號：2125398
[Abstract]:Degenerative disease of positive intervertebral disc is a common and frequent disease in clinic. At present, the main factors influencing degeneration of intervertebral disc are inflammatory reaction, oxidative stress and mechanical stress. Under the action of these factors, the endplate of the intervertebral disc has pathological changes and calcification of the endplate, which leads to nutrient dispersion disorder, which is the initiator of disc degeneration, and the endplate chondrocytes are hypertrophic. Apoptosis plays a major role in calcification of endplate. But at present, the degeneration of chondrocytes
【作者單位】： 廣州中醫(yī)藥大學研究生院;廣州中醫(yī)藥大學第一附屬醫(yī)院脊柱骨科;
【分類號】：R681.5
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，本文編號：2125398
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