本文選題：干細(xì)胞 + 移植��； 參考：《東南大學(xué)學(xué)報(醫(yī)學(xué)版)》2016年06期

【摘要】：目的:系統(tǒng)評價及Meta分析干細(xì)胞移植治療缺血性腦卒中的臨床療效和安全性。方法:計算機(jī)檢索Cochrane Library、Pub Med、Ovid、CBM、中國知網(wǎng)、萬方和維普數(shù)據(jù)庫,檢索干細(xì)胞移植治療缺血性腦卒中的隨機(jī)對照研究(RCT),檢索時限從建庫至2015年12月。所有檢索后的文獻(xiàn)由2位作者按照納入與排除標(biāo)準(zhǔn)分別獨立進(jìn)行文獻(xiàn)篩選和數(shù)據(jù)資料提取及偏倚風(fēng)險評價,并采用Rev Man5.3軟件進(jìn)行Meta分析。結(jié)果:共納入16個研究(18個獨立干預(yù)治療)進(jìn)行Meta分析,得到的結(jié)果如下(使用各結(jié)局指標(biāo)的基線終值差進(jìn)行合并):神經(jīng)功能缺損評分(NIHSS)(MD=1.57,95%CI 0.64~2.51,I2=57%,P=0.001)、運動功能FMA(MD=4.23,95%CI 3.08~5.38,I2=0%,P0.000 01)、日常生活能力Barthel(MD=8.37,95%CI 4.83~11.91,I2=63%,P0.000 01)和功能獨立性FIM(MD=8.89,95%CI 4.70~13.08,I2=79%,P0.000 1)等結(jié)局指標(biāo)合并后(干細(xì)胞移植組和對照組的均數(shù)差MD)的結(jié)果均是有利于干細(xì)胞移植治療組,且各差異均有統(tǒng)計學(xué)意義。結(jié)論:干細(xì)胞治療對缺血性腦卒中病人的神經(jīng)功能和日常生活質(zhì)量均有不同程度的改善,且不良反應(yīng)少。但是還需要更多高質(zhì)量的大數(shù)據(jù)隨機(jī)對照研究來進(jìn)一步證實干細(xì)胞移植治療的有效性。
[Abstract]:Objective: to evaluate the efficacy and safety of stem cell transplantation in the treatment of ischemic stroke. Methods: the Cochrane Library Pub MedOvidCIM, the China Zhiwang, Wanfang and Weipu databases, and the randomized controlled study of stem cell transplantation in the treatment of ischemic stroke were searched. The search time was from the establishment of the database to December 2015. All the retrieved documents were independently selected by the two authors according to the inclusion and exclusion criteria, and the data extraction and bias risk evaluation were carried out, respectively, and Meta analysis was carried out with Rev Man5.3 software. Results: Meta analysis was performed in 16 subjects (18 independent intervention therapy). 寰楀埌鐨勭粨鏋滃涓，

本文編號：1889938