術前中性粒細胞與淋巴細胞比值預測可切除泌尿系腫瘤預后的價值:系統(tǒng)綜述和薈萃分析(英文)
發(fā)布時間:2021-04-24 14:31
目的術前中性粒細胞與淋巴細胞比值(NLR)與多種惡性腫瘤的預后密切相關,但是,NLR對可切除泌尿系腫瘤預后的影響尚不確定。因此,此系統(tǒng)綜述和薈萃分析旨在探討術前NLR在預測可切除泌尿系腫瘤預后方面的價值。方法我們通過檢索Embase、PubMed/MEDLINE和Cochrane數(shù)據(jù)庫,依據(jù)納入和排除標準篩選文獻,最終納入25項研究,其中包括15950例受試對象。采用風險比(HRs)及其95%可信區(qū)間(CIs)評估術前NLR與可切除泌尿系腫瘤患者的總生存期(OS)及腫瘤特異性生存期(CSS)的關系。結果結果表明對于患有可切除泌尿系惡性腫瘤的患者,術前NLR能預測其預后。NLR越高,患者的OS(HR=1.40,95%CI:1.26~1.54,P<0.001)和CSS越短(HR=1.43,95%CI:1.27~1.59,P<0.001)。此外,不論患者種族或術前NLR閾值高低,術前NLR升高均能提示腎細胞癌(OS:HR=2.06,95%CI=1.54~2.76,P=0.131;CSS:HR=2.46,95%CI=1.46~4.16,P=0.178)、上尿路上皮癌(OS:HR=1...
【文章來源】:Chinese Medical Sciences Journal. 2020,35(03)CSCD
【文章頁數(shù)】:10 頁
【文章目錄】:
MATERIALS AND METHODS
Literature search
Inclusion and exclusion criteria
Data extraction and quality control
Statistical analysis
RESULTS
Characteristics of the included studies
Overall survival
Cancer-specific survival
Heterogeneity
Publication bias
DISCUSSION
Conflict of Interests Statement
本文編號:3157529
【文章來源】:Chinese Medical Sciences Journal. 2020,35(03)CSCD
【文章頁數(shù)】:10 頁
【文章目錄】:
MATERIALS AND METHODS
Literature search
Inclusion and exclusion criteria
Data extraction and quality control
Statistical analysis
RESULTS
Characteristics of the included studies
Overall survival
Cancer-specific survival
Heterogeneity
Publication bias
DISCUSSION
Conflict of Interests Statement
本文編號:3157529
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