發(fā)布時間：2019-06-17 20:00

【摘要】：目的探討帕瑞昔布鈉復(fù)合地佐辛對脛腓骨骨折切開復(fù)位內(nèi)固定手術(shù)患者超前鎮(zhèn)痛的效果。方法擇期行脛腓骨骨折切開復(fù)位內(nèi)固定手術(shù)患者120例,隨機分為四組各30例。麻醉誘導(dǎo)后切皮前20 min,C組靜脈注射生理鹽水5 m L,P組靜脈注射帕瑞昔布鈉40 mg,D組靜脈注射地佐辛0.1 mg/kg,PD組靜脈注射帕瑞昔布鈉40mg和地佐辛0.1 mg/kg。術(shù)畢記錄蘇醒時間、意識恢復(fù)時間、拔管時間、拔管后10 min Riker鎮(zhèn)靜躁動評分(SAS);記錄術(shù)后1、2、4、12、24 h的靜、動態(tài)VAS評分及MAP、HR、Sp O2;記錄術(shù)后24 h內(nèi)按壓鎮(zhèn)痛泵次數(shù)。結(jié)果四組蘇醒時間、拔管時間、意識恢復(fù)時間、MAP、HR、Sp O2、術(shù)后24 h內(nèi)按壓鎮(zhèn)痛泵次數(shù)差異無統(tǒng)計學(xué)意義(P均0.05)。與C組比較,PD組的Riker鎮(zhèn)靜躁動評分降低(P0.05)。與P組、D組比較,PD組術(shù)后1、2、12 h靜、動態(tài)VAS評分均降低(P均0.05)。結(jié)論帕瑞昔布鈉復(fù)合地佐辛對脛腓骨骨折切開復(fù)位內(nèi)固定手術(shù)患者超前鎮(zhèn)痛的效果優(yōu)于單獨應(yīng)用帕瑞昔布鈉或地佐辛。
[Abstract]:Objective to investigate the effect of parexib sodium combined with dizoxine on preemptive analgesia in patients undergoing open reduction and internal fixation of tibia and fibula fracture. Methods 120 patients undergoing open reduction and internal fixation of tibia and fibula fractures were randomly divided into four groups (n = 30). After anaesthesia induction, normal saline 5 mL was injected intravenously in 20 min,C group before anesthesia induction, parexib sodium 40mg was injected intravenously in group P, and parexib sodium 40mg and dizoxacin 0.1 mg/kg. were injected intravenously in group D with dizoxacin 0.1 mg/kg,PD. The recovery time and consciousness recovery time were recorded at the end of operation. 10 min Riker sedation and restlessness score after extubation were recorded at 1, 2, 4, 12, 24 h static and dynamic VAS scores and MAP,HR,Sp O 2, and the number of pressing analgesia pumps within 24 hours after extubation was recorded. Results there was no significant difference in recovery time, extubation time, consciousness recovery time, MAP,HR,Sp O 2 and the times of pressing analgesia pump within 24 hours after operation. Compared with group C, the score of Riker sedation and restlessness in PD group was lower than that in group C (P 0.05). Compared with group P and group D, the scores of static and dynamic VAS in PD group were decreased at 1 h, 2 h and 12 h after operation (all P 0.05). Conclusion the effect of parexib sodium combined with dizoxine on preemptive analgesia in patients undergoing open reduction and internal fixation of tibia and fibula fracture is better than that of parexib sodium or dizoxacin alone.
【作者單位】： 寧夏醫(yī)科大學(xué);寧夏醫(yī)科大學(xué)總醫(yī)院;
【分類號】：R614

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