本文關(guān)鍵詞：維吾爾族口腔鱗狀細胞癌患者中血清鱗狀細胞癌抗原的表達研究　出處：《國際口腔醫(yī)學(xué)雜志》2016年06期 　論文類型：期刊論文

  更多相關(guān)文章： 口腔鱗狀細胞癌 鱗狀細胞癌抗原 腫瘤標志物 手術(shù) 化放療

【摘要】：目的探討維吾爾族口腔鱗狀細胞癌(OSCC)患者血清中鱗狀細胞癌抗原(SCC-Ag)的表達。方法采用化學(xué)發(fā)光法檢測90例維吾爾族OSCC患者(OSCC組)和90例維吾爾族其他口腔惡性腫瘤患者(口腔非OSCC惡性腫瘤組)、101例維吾爾族口腔良性腫瘤患者(良性腫瘤組)和120例維吾爾族正常對照者(正常組)的血清SCC-Ag水平,并對其中60例OSCC和60例口腔非OSCC惡性腫瘤患者治療前后SCC-Ag水平進行檢測,分析SCC-Ag在OSCC診斷、治療療效中的意義。結(jié)果OSCC組的SCC-Ag水平明顯高于口腔非OSCC惡性腫瘤組(P=0.002),良性腫瘤組(P=0.001)和正常組(P=0.001)。OSCC患者血清SCC-Ag陽性串為43.3%(39/90),明顯高于其他3組(P=0.0001)。OSCC患者TNM晚期的術(shù)前SCC-Ag水平的表達高于早期水平(P0.05)。復(fù)發(fā)組和未復(fù)發(fā)組的術(shù)前、術(shù)后、放化療后SCC-Ag水平相比較,差異均有統(tǒng)計學(xué)意義(P0.05)。手術(shù)及放化療前后鱗狀細胞癌患者血清SCC-Ag水平變化差異有統(tǒng)計學(xué)意義(P0.01),然而,在口腔非OSCC惡性腫瘤組治療療效差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論血清SCC-Ag對維吾爾族OSCC患者的早期診斷敏感性不高,但在評價治療療效,預(yù)測腫瘤復(fù)發(fā)方面有重要的臨床意義。
[Abstract]:Objective to investigate the expression of squamous cell carcinoma antigen (SCC-Ag) in the serum of Uygur oral squamous cell carcinoma (OSCC) patients. OSCC group) and 90 cases of other Uygur oral malignant tumors (oral non-#en1# malignant tumor group). Serum SCC-Ag levels were measured in 101 patients with oral benign tumor (benign tumor group) and 120 normal controls (normal group). The levels of SCC-Ag in 60 cases of OSCC and 60 cases of non-#en1# malignant tumor of oral cavity were detected before and after treatment, and the diagnosis of SCC-Ag in OSCC was analyzed. Results the level of SCC-Ag in OSCC group was significantly higher than that in oral non-#en2# malignant tumor group (P 0.002). The serum SCC-Ag positive sequence in benign tumor group and normal group was 43.3% 39 / 90). The expression of SCC-Ag in the late stage of TNM was significantly higher than that in the other three groups. The expression of SCC-Ag in the late stage of TNM was higher than that in the early stage (P 0.05). Postoperative SCC-Ag levels were compared after radiotherapy and chemotherapy. There were significant differences in serum SCC-Ag levels before and after operation and radiotherapy and chemotherapy in patients with squamous cell carcinoma (P 0.05). However, there was a significant difference in serum SCC-Ag level between patients with squamous cell carcinoma before and after operation. There was no significant difference in the curative effect in oral non-#en0# malignant tumor group (P 0.05). Conclusion the early diagnostic sensitivity of serum SCC-Ag in Uygur patients with OSCC is not high. But it has important clinical significance in evaluating therapeutic effect and predicting tumor recurrence.
【作者單位】： 新疆維吾爾自治區(qū)人民醫(yī)院頜面外科;北京大學(xué)口腔醫(yī)院口腔頜面外科;上海交通大學(xué)醫(yī)學(xué)院附屬第九人民醫(yī)院口腔頜面外科;
【基金】：中華口腔醫(yī)學(xué)會西部行口腔醫(yī)學(xué)臨床科研基金(CSA-W-2014-2)~~
【分類號】：R739.85
【正文快照】： 頭頸部惡性腫瘤在全世界范圍內(nèi)的發(fā)病率較高,口腔癌位居全身惡性腫瘤的第六位。中國口腔頜面部惡性腫瘤為全身惡性腫瘤的8.2%,其中,口腔鱗狀細胞癌(oral squamous cell carci-noma,OSCC)是口腔頜面部惡性腫瘤中最多見的類型,約占80%以上[1]。在新疆,維吾爾族口腔頜面部惡性腫

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