【摘要】：目的比較艾司西酞普蘭與氟西汀治療老年抑郁癥的療效。方法對艾司西酞普蘭與氟兩汀治療老年抑郁癥對照研究進行系統(tǒng)評價,應用循證醫(yī)學的研究方法,使用專用的統(tǒng)計分析軟件Revman 5.1進行Meta分析。結果 7篇隨機對照研究滿足納入標準。Meta分析的結果顯示,療程為1、2、4 w時,兩組漢密爾頓抑郁量表(HAMD)評分差異無統(tǒng)計學意義(Z=0.71、0.21、1.2,P=0.48、0.83、0.20),此時艾司西酞普蘭與氟西汀療效相當;療程為6 w時,兩組HAMD評分差異有統(tǒng)計學意義(Z=2.13,P=0.03),此時艾司西酞普蘭療效優(yōu)于氟西汀。比較療程6 w結束后的有效率,其OR值為1.51(95%CI:0.93~2.45),兩組之間有效率相當(Z=1.65,P=0.10)。比較療程6 w結束后的痊愈率,其中OR值為1.17(95%CI:0.84~1.63),兩組之間痊愈率相當(Z=0.93,P=0.35)。比較療程6 w結束后的不良反應,其中OR值為0.86(95%CI:0.53~1.39),兩組之間出現(xiàn)的不良反應無差異(Z=0.61,P=0.54)。結論艾司西酞普蘭用于治療老年抑郁癥是一種安全有效的抗抑郁藥物,且艾司西酞普蘭較氟西汀能夠更好地改善老年抑郁癥癥狀。
[Abstract]:Objective to compare the efficacy of escitalopram and fluoxetine in the treatment of elderly depression. Methods the comparative study of escitalopram and fluodipine in the treatment of elderly depression was systematically evaluated. Meta analysis was carried out by using evidence-based medicine (EBM) and the special statistical analysis software Revman 5.1. Results the results of meta-analysis showed that there was no significant difference in (HAMD) score between the two groups when the course of treatment was 1, 2, 4 weeks (Z 鈮，

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