【摘要】：目的探討聽覺統(tǒng)合訓練對額葉顱腦損傷患者記憶功能、認知功能和血清腦源性神經(jīng)營養(yǎng)因子(BDNF)的影響。方法采用數(shù)字隨機法將40例額葉顱腦損傷患者分為對照組(20例)和聽覺統(tǒng)合訓練組(20例)。對照組給予常規(guī)康復治療;聽覺統(tǒng)合訓練組給予聽覺統(tǒng)合訓練,1次/d,5次/w。治療前后,分別采用修訂的韋氏記憶量表(WMS-CR)評測工作記憶,威斯康星評測系統(tǒng)(WCST)評測認知功能,酶聯(lián)免疫吸附試驗檢測血清BDNF的濃度。結果與對照組比較,視聽感覺統(tǒng)合訓練組WMS-CR評測中的理解、背數(shù)和積累分測驗得分顯著增高;WCST評測的完成分類數(shù)、正確應答數(shù)、概念化水平百分數(shù)、非持續(xù)性錯誤數(shù)項評分優(yōu)于對照組,但總應答數(shù)、錯誤應答數(shù)、持續(xù)性應答數(shù)、持續(xù)性錯誤數(shù)差異無統(tǒng)計學意義(P0.05);BDNF血清濃度較對照組升高(P0.05)。結論聽覺統(tǒng)合訓練可改善額葉顱腦損傷患者的記憶功能、認知功能,提高BDNF水平。
[Abstract]:Objective to investigate the effects of auditory integrative training on memory function, cognitive function and serum brain-derived neurotrophic factor (BDNF) in patients with frontal lobe craniocerebral injury. Methods 40 patients with frontal lobe craniocerebral injury were randomly divided into control group (20 cases) and auditory integrated training group (20 cases). The control group received routine rehabilitation and the auditory integrative training group received auditory integrative training once a day for 5 times per week. Before and after treatment, working memory was evaluated by revised Wechsler memory scale (WMS-CR), cognitive function was assessed by Wisconsin (WCST), and serum BDNF concentration was measured by Elisa. Results compared with the control group, the scores of comprehension, back count and accumulation subtest in the audiovisual sensory integration training group were significantly higher than those in the control group. The scores of complete classification, correct response, conceptualization level, non-persistent error number, WCST evaluation were better than those of the control group, but the total number of responses, the number of error responses, and the number of persistent responses were better than those of the control group. There was no significant difference in the number of persistent errors (P0.05). The serum concentration of BDNF was higher than that of control group (P0.05). Conclusion auditory integrative training can improve the memory function, cognitive function and BDNF level of patients with frontal lobe craniocerebral injury.
【作者單位】： 天津市第五中心醫(yī)院重癥醫(yī)學科;華北理工大學附屬醫(yī)院;
【基金】：河北省科技廳支撐課題(13277776D)
【分類號】：R651.15

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