【摘要】：目的探索自行研發(fā)10.0 MHz超聲導(dǎo)管以不同參數(shù)組合消融腎動脈周圍神經(jīng)時溫度場的分布,并觀察在體條件下不同劑量聲能產(chǎn)生的去交感神經(jīng)效果。方法超聲導(dǎo)管消融犬離體腎動脈,以針式熱電偶檢測不同聲功率消融不同時間時距腎動脈內(nèi)膜不同距離處的溫度。選擇溫度≥51℃的組合行活體消融。測量消融前及消融后1周的血壓,取腎動脈及周圍組織行病理學(xué)檢查。結(jié)果腎動脈周圍溫度與消融功率及時間呈正相關(guān),各組溫度均在5 mm處達(dá)峰值。1.5 W×30s消融組、3.0 W×15s消融組及3.0 W×30s消融組在5mm、7mm處達(dá)有效消融溫度。消融1周后消融組收縮壓和舒張壓下降幅度分別為(8.77±0.78)mmHg/(6.44±0.60)mmHg,(9.78±1.86)mmHg/(6.36±1.49)mmHg,(13.34±1.75)mmHg/(12.20±2.44)mmHg(P0.05)。肉眼觀測腎動脈周圍無損傷,HE染色見腎周圍神經(jīng)空泡樣變。結(jié)論 10.0 MHz超聲導(dǎo)管消融腎周圍神經(jīng),在距內(nèi)膜5~7mm處達(dá)有效溫度;在體實(shí)驗(yàn)初步證明其應(yīng)用于腎去交感的有效性及安全性。
[Abstract]:Objective to investigate the distribution of temperature field during the ablation of peripheral nerves of renal artery by 10 MHz ultrasound catheter with different parameters, and to observe the effect of different doses of sound energy on dessympathetic nerve in vivo. Methods Ultrasonic catheter ablation of isolated canine renal artery was performed and the temperature at different distances from the renal artery intima was measured by needle thermocouple. The combination of temperature 鈮，

本文編號：2355430