發(fā)布時(shí)間：2018-02-19 18:40

  本文關(guān)鍵詞： 軀體化障礙 腦 磁共振彌散張量成像 各向異性分?jǐn)?shù) 表觀彌散系數(shù)　出處：《新疆醫(yī)科大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：運(yùn)用磁共振彌散張量成像定量指標(biāo)測(cè)定軀體化障礙(SD)患者腦內(nèi)超微結(jié)構(gòu)的變化,以期對(duì)軀體化障礙的發(fā)病機(jī)制、臨床研究提供有價(jià)值的依據(jù)。方法：采用3.0T磁共振對(duì)28例SD患者及28例正常對(duì)照進(jìn)行DTI掃描,測(cè)量受試者左右側(cè)額葉白質(zhì)纖維、胼胝體、左右側(cè)扣帶束、左右上、下縱束感興趣區(qū)內(nèi)主要白質(zhì)纖維束以及左右側(cè)小腦齒狀核的表觀彌散系數(shù)(ADC)和各向異性分?jǐn)?shù)(FA)值,并進(jìn)行兩組間比較,評(píng)估其在病例組和對(duì)照組之間的差異,分析兩組間FA值有統(tǒng)計(jì)學(xué)差異的腦區(qū)的FA值與病程的相關(guān)性。結(jié)果：患者組胼胝體膝部FA值較對(duì)照組降低,左側(cè)下縱束、左右側(cè)扣帶束水平部、左扣帶束后部的ADC值較對(duì)照組明顯升高,FA值較對(duì)照組明顯降低(P0.05),有差異腦區(qū)的FA值與病程之間無(wú)統(tǒng)計(jì)學(xué)相關(guān)性。SD組右側(cè)小腦齒狀核FA值較左側(cè)升高,二者之間差異有統(tǒng)計(jì)學(xué)意義,正常組左右側(cè)小腦髓質(zhì)和齒狀核、正常和病例組間相應(yīng)小腦髓質(zhì)和齒狀核ADC、FA值比較無(wú)統(tǒng)計(jì)學(xué)差異。結(jié)論：軀體化障礙患者優(yōu)勢(shì)半球扣帶束、下縱束神經(jīng)纖維完整性降低,存在超微結(jié)構(gòu)異常,SD患者雙側(cè)小腦齒狀核存在明顯不對(duì)稱性,可能是軀體化障礙患者病理生理基礎(chǔ)之一,但是病程與神經(jīng)纖維損傷程度未發(fā)現(xiàn)明顯相關(guān)性。
[Abstract]:Objective: to determine the changes of brain ultrastructure in patients with somatization disorder (SDD) by using the quantitative index of magnetic resonance diffusion Zhang Liang imaging, in order to explore the pathogenesis of somatization disorder. Methods: DTI scanning was performed on 28 SD patients and 28 normal controls with 3.0T magnetic resonance imaging. The white matter fibers of left and right frontal lobe, corpus callosum, cingulate band of left and right were measured. The apparent diffusion coefficient (ADCC) and anisotropic fraction (FAA) of the main white matter fiber bundle and the left and right cerebellar dentate nuclei in the region of interest of the lower longitudinal bundle were compared and compared between the two groups to evaluate the difference between the case group and the control group. Results: the FA value of the genu of corpus callosum in the patients group was lower than that of the control group. The ADC value of the posterior part of the left cingulate band was significantly higher than that of the control group. The FA value of the right cerebellar dentate nucleus in SD group was higher than that of the left cerebellar dentate nucleus. There was no significant difference in ADCFA between the left and right cerebellum medulla and dentate nucleus in normal group, and the corresponding ADCFA value in cerebellar medulla and dentate nucleus between normal group and case group. Conclusion: the dominant hemispheric cingulate bundle is found in patients with somatization disorder. The nerve fiber integrity of the lower longitudinal bundle decreased and the bilateral dentate nucleus of the cerebellum showed obvious asymmetry in the patients with abnormal ultrastructure, which may be one of the pathophysiological bases of the patients with somatization disorder. However, no significant correlation was found between the course of disease and the degree of nerve fiber injury.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R445.2

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